ArticleJournal of molecular biology2007
Comparison of fungal 80 S ribosomes by cryo-EM reveals diversity in structure and conformation of rRNA expansion segments.
Article in Journal of molecular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- rRNA expansion segment 7 in eukaryotes: from Signature Fold to tentacles.Nucleic acids research · 2022Article
- Endonucleolytic cleavage in the expansion segment 7 of 25S rRNA is an early marker of low-level oxidative stress in yeast.The Journal of biological chemistry · 2017Article
- Homoiterons and expansion in ribosomal RNAs.FEBS open bio · 2015Article
- Structural characterization of a eukaryotic chaperone--the ribosome-associated complex.Nature structural & molecular biology · 2013Article
- Article
- Comprehensive molecular structure of the eukaryotic ribosome.Structure (London, England : 1993) · 2009Article
- The eukaryotic ribosome: current status and challenges.The Journal of biological chemistry · 2009Review
- Visualization of the eEF2-80S ribosome transition-state complex by cryo-electron microscopy.Journal of molecular biology · 2008Article
- Ribosomal RNAs are tolerant toward genetic insertions: evolutionary origin of the expansion segments.Nucleic acids research · 2008Article
- The small subunit processome in ribosome biogenesis—progress and prospects.Wiley interdisciplinary reviews. RNAReview
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Compared to the prokaryotic 70 S ribosome, the eukaryotic 80 S ribosome contains additional ribosomal proteins and extra segments of rRNA, referred to as rRNA expansion segments (ES). These eukaryotic-specific rRNA ES are mainly on the periphery of the 80 S ribosome, as revealed by cryo-electron microscopy (cryo-EM) studies, but their precise function is not known. To address the question of whether the rRNA ES are structurally conserved among 80 S ribosomes of different fungi we performed cryo-electron microscopy on 80 S ribosomes from the thermophilic fungus Thermomyces lanuginosus and compared it to the Saccharomyces cerevisiae 80 S ribosome. Our analysis reveals general structural conservation of the rRNA expansion segments but also changes in ES27 and ES7/39, as well as the absence of a tertiary interaction between ES3 and ES6 in T. lanuginosus. The differences provide a hint on the role of rRNA ES in regulating translation. Furthermore, we show that the stalk region and interactions with elongation factor 2 (eEF2) are different in T. lanuginosus, exhibiting a more extensive contact with domain I of eEF2.
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