Evidence map›Paper›PMID 17433777›Full record

ArticleTrends in parasitology2007

Introducing histone modification in trypanosomes.

David Horn

Abstract read
In one paragraph

Article in Trends in parasitology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Localization of Epigenetic Markers inPathogens (Basel, Switzerland) · 2022
    Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Regulation of gene expression in protozoa parasites.Journal of biomedicine & biotechnology · 2010
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

David HornLondon School of Hygiene & Tropical Medicine, Keppel Street, London, UK. david.horn@lshtm.ac.uk

Funding

Wellcome Trust 079457
6 · The paper itself

Abstract

Nuclear DNA is wrapped around histones. Vigorous research over the past decade has established a central role for histone post-translational modification in controlling the DNA-protein interactions that are required for successful growth and propagation. Recent work now provides a description of acetylated and methylated residues in the divergent trypanosome core histones. Future studies should provide insights into the genomic distribution of each modification and their roles in growth and pathogenesis.

Indexed as

Protein Processing, Post-TranslationalAcetylationAnimalsDNA, ProtozoanHistonesMass SpectrometryMethylationProtozoan ProteinsTrypanosoma brucei bruceiTrypanosoma cruziDNA, ProtozoanHistonesProtozoan Proteins

Identifiers

PMID17433777
PMCPMC3828116

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.