ArticleDevelopmental biology2007
Wingless/Wnt signal transduction requires distinct initiation and amplification steps that both depend on Arrow/LRP.
Article in Developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Wnt signalosomes: What we know that we do not know.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Mutant APC reshapes Wnt signaling plasma membrane nanodomains by altering cholesterol levels via oncogenic β-catenin.Nature communications · 2023Article
- Extensive loss of Wnt genes in Tardigrada.BMC ecology and evolution · 2021Article
- Histone lysine methyltransferase Pr-set7/SETD8 promotes neural stem cell reactivation.EMBO reports · 2021Article
- Destruction complex dynamics: Wnt/β-catenin signaling alters Axin-GSK3β interactionsDevelopment (Cambridge, England) · 2019Article
- HypermethylatedAmerican journal of translational research · 2018Article
- The Drosophila tankyrase regulates Wg signaling depending on the concentration of Daxin.Cellular signalling · 2014Article
- The way Wnt works: components and mechanism.Growth factors (Chur, Switzerland) · 2013Review
- Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling.Cold Spring Harbor perspectives in biology · 2012Review
- Dickkopf1--a new player in modelling the Wnt pathway.PloS one · 2011Article
- Article
- Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors.Genes & development · 2010Article
- The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage.PloS one · 2009Article
- Wnt signaling from development to disease: insights from model systems.Cold Spring Harbor perspectives in biology · 2009Review
- Wnt/beta-catenin signaling: components, mechanisms, and diseases.Developmental cell · 2009Review
- Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling.The Journal of biological chemistry · 2009Article
- Unexpectedly robust assembly of the Axin destruction complex regulates Wnt/Wg signaling in Drosophila as revealed by analysis in vivo.Developmental biology · 2008Article
- Wnt signaling: the good and the bad.Acta biochimica et biophysica Sinica · 2008Article
- Wnt signal amplification via activity, cooperativity, and regulation of multiple intracellular PPPSP motifs in the Wnt co-receptor LRP6.The Journal of biological chemistry · 2008Article
- Wnt/beta-catenin signaling: new (and old) players and new insights.Current opinion in cell biology · 2008Review
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Authors and funding
3 authors.
Funding
Abstract
Members of the Wg/Wnt family provide key intercellular signals during embryonic development and in the maintenance of homeostatic processes, but critical aspects of their signal transduction pathways remain controversial. We have found that canonical Wg signaling in Drosophila involves distinct initiation and amplification steps, both of which require Arrow/LRP. Expressing a chimeric Frizzled2-Arrow protein in flies that lack endogenous Wg or Arrow showed that this construct functions as an activated Wg receptor but is deficient in signal amplification. In contrast, a chimeric Arrow protein containing the dimerization domain of Torso acted as a potent amplifier of Wg signaling but could not initiate Wg signaling on its own. The two chimeric proteins synergized, so that their co-expression largely reconstituted the signaling levels achieved by expressing Wg itself. The amplification function of Arrow/LRP appears to be particularly important for long-range signaling, and may reflect a general mechanism for potentiating signals in the shallow part of a morphogen gradient.
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Registered trials
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