ArticleBiochemical and biophysical research communications2007
Prolactin upregulates its receptors and inhibits lipolysis and leptin release in male rat adipose tissue.
Article in Biochemical and biophysical research communications, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 56 citations in OpenAlex.
- Prolactin and heat stress; focus on domestic ruminants.Journal of animal science · 2025Review
- Effects of Prolactin Inhibition on Lipid Metabolism in Goats.Animals : an open access journal from MDPI · 2024Article
- Dopamine receptor agonists mechanism of actions on glucose lowering and their connections with prolactin actions.Frontiers in clinical diabetes and healthcare · 2023Review
- The beneficial metabolic actions of prolactin.Frontiers in endocrinology · 2022Review
- Novel insights linking BRCA1-IRIS role in mammary gland development to formation of aggressive PABCs: the case for longer breastfeeding.American journal of cancer research · 2022Article
- Differential Level of RXFP3 Expression in Dopaminergic Neurons Within the Arcuate Nucleus, Dorsomedial Hypothalamus and Ventral Tegmental Area of RXFP3-Cre/tdTomato Mice.Frontiers in neuroscience · 2020Article
- Association of Full Breastfeeding Duration with Postpartum Weight Retention in a Cohort of Predominantly Breastfeeding Women.Nutrients · 2019Article
- NCB5OR Deficiency in the Cerebellum and Midbrain Leads to Dehydration and Alterations in Thirst Response, Fasted Feeding Behavior, and Voluntary Exercise in Mice.Cerebellum (London, England) · 2018Article
- Adrenergic hormones induce extrapituitary prolactin gene expression in leukocytes-potential implications in obesity.Scientific reports · 2018Article
- Neuroendocrine Regulation of Metabolism.Journal of neuroendocrinology · 2016Review
- Effects of High-Fat Diet on Stress Response in Male and Female Wildtype and Prolactin Knockout Mice.PloS one · 2016Article
- Is prolactin the missing link in adipose tissue dysfunction of polycystic ovary syndrome patients?Endocrine · 2016Article
- Paradoxical effects of partial leptin deficiency on bone in growing female mice.Anatomical record (Hoboken, N.J. : 2007) · 2015Article
- The role of prolactin in andrology: what is new?Reviews in endocrine & metabolic disorders · 2015Review
- Heat stress increases insulin sensitivity in pigs.Physiological reports · 2015Article
- Adipokine pathways are altered in hippocampus of an experimental mouse model of Alzheimer's disease.The journal of nutrition, health & aging · 2015Article
- Endocrine regulation of bone and energy metabolism in hibernating mammals.Integrative and comparative biology · 2014Review
- Article
- Effects of dopamine on leptin release and leptin gene (OB) expression in adipocytes from obese and hypertensive patients.International journal of nephrology and renovascular disease · 2013Article
- Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Prolactin (PRL) is recognized as a metabolic regulator during lactation, but little information exists on its actions in male adipose tissue. We examined whether PRL affects the expression of its receptors (PRLR), lipolysis, and adipokine secretion in male rats. Both long and short PRLR isoforms were induced 40-50-fold during differentiation of epididymal preadipocytes, with a 10-fold higher expression of the long isoform. PRL upregulated both isoforms before and after differentiation. PRL suppressed lipolysis in epididymal explants and mature adipocytes in a dose- and time-dependent manner, which was reversed by a Jak2 inhibitor. PRL also inhibited leptin, but not adiponectin, release. We conclude that PRL inhibits lipolysis and leptin release by acting directly on adipocytes via interaction with either of its receptors and activation of a Jak2-dependent signaling pathway(s). This is the first demonstration of substantial effects of PRL on male adipocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.