ArticleAlcoholism, clinical and experimental research2007
Lactational state modifies alcohol pharmacokinetics in women.
Article in Alcoholism, clinical and experimental research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Population pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant women with malaria.Malaria journal · 2011Trial
- Breastfeeding and prolactin levels in lactating women with a family history of alcoholism.Pediatrics · 2010Trial
- Breast pumping and lactational state exert differential effects on ethanol pharmacokinetics.Alcohol (Fayetteville, N.Y.) · 2010Trial
- Effects of breast pumping on the pharmacokinetics and pharmacodynamics of ethanol during lactation.Clinical pharmacology and therapeutics · 2008Trial
- Recent advances in alcohol metabolism: from the gut to the brain.Physiological reviews · 2025Review
- Glucagon-like peptide-1, fibroblast growth factor 21, and other endocrine responses to alcohol ingestion in women before and after metabolic surgery.Frontiers in pharmacology · 2025Article
- The glucagon-like peptide-1 and other endocrine responses to alcohol ingestion in women with versus without metabolic surgery.Addiction biology · 2024Article
- Recommendations for the establishment and operation of a donor human milk bank.Nutrition reviews · 2023Article
- Alcohol sensitivity in women after undergoing bariatric surgery: a cross-sectional study.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2020Article
- Pharmacokinetics and pharmacodynamics of artesunate and dihydroartemisinin following oral treatment in pregnant women with asymptomatic Plasmodium falciparum infections in Kinshasa DRC.Malaria journal · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundGiven the physiological adaptations of the digestive system during lactation, the present study tested the hypothesis that lactation alters alcohol pharmacokinetics.
methodsLactating women who were exclusively breastfeeding a 2- to 5-month-old infant and 2 control groups of nonlactating women were studied. The first control group consisted of women who were exclusively formula-feeding similarly aged infants, whereas the other consisted of women who had never given birth. A within-subjects design study was conducted such that women drank a 0.4 g/kg dose of alcohol following a 12-hour overnight fast during one test session (fasted condition) or 60 minutes after consuming a standard breakfast during the other (fed condition). Blood alcohol concentration (BAC) levels and mood states were obtained at fixed intervals before and after alcohol consumption.
resultsUnder both conditions, the resultant BAC levels at each time point were significantly lower and the area under the blood alcohol time curve were significantly smaller in lactating women when compared with the 2 groups of nonlactating women. That such changes were due to lactation per se and not due to recent parturient events was suggested by the finding that alcohol pharmacokinetics of nonlactating mothers, who were tested at a similar time postpartum, were no different from women who had never given birth. Despite lower BAC levels in lactating mothers, there were no significant differences among the 3 groups of women in the stimulant effects of alcohol. However, lactating women did differ in the sedative effects of alcohol when compared with nulliparous but not formula-feeding mothers. That is, both groups of parous women felt sedated for shorter periods of time when compared with nulliparous women.
conclusionsThe systemic availability of alcohol was diminished during lactation. However, the reduced availability of alcohol in lactating women did not result in corresponding changes in the subjective effects of alcohol.
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