ArticlePLoS pathogens2007
Molecular basis for a lack of correlation between viral fitness and cell killing capacity.
Article in PLoS pathogens, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 51 citations in OpenAlex.
- Adaptation without Dominance in Pseudomonas syringae Pathovars.Microbial ecology · 2025Article
- Colorado Tick Fever Virus: Quantification, Propagation, Storage, and Detection.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Virus-like Particles: Measures and Biological Functions.Viruses · 2022Review
- Foot-and-mouth disease virus VP1 target the MAVS to inhibit type-I interferon signaling and VP1 E83K mutation results in virus attenuation.PLoS pathogens · 2020Article
- Manipulating virulence factor availability can have complex consequences for infections.Evolutionary applications · 2017Article
- Differential Persistence of Foot-and-Mouth Disease Virus in African Buffalo Is Related to Virus Virulence.Journal of virology · 2016Article
- Constrained evolvability of interferon suppression in an RNA virus.Scientific reports · 2016Article
- The hypervariable amino-terminus of P1 protease modulates potyviral replication and host defense responses.PLoS pathogens · 2014Article
- Relationship between within-host fitness and virulence in the vesicular stomatitis virus: correlation with partial decoupling.Journal of virology · 2012Article
- Competition-colonization trade-off promotes coexistence of low-virulence viral strains.Journal of the Royal Society, Interface · 2012Article
- Viral population dynamics and virulence thresholds.Current opinion in microbiology · 2012Review
- Viral quasispecies evolution.Microbiology and molecular biology reviews : MMBR · 2012Review
- Different domains of the RNA polymerase of infectious bursal disease virus contribute to virulence.PloS one · 2012Article
- Quasispecies as a matter of fact: viruses and beyond.Virus research · 2011Review
- In vivo fitness associated with high virulence in a vertebrate virus is a complex trait regulated by host entry, replication, and shedding.Journal of virology · 2011Article
- Article
- A mutant of infectious Asia 1 serotype foot-and-mouth disease virus with the deletion of 10-amino-acid in the 3A protein.Virus genes · 2010Article
- Models of RNA virus evolution and their roles in vaccine design.Immunome research · 2010Article
- Competition-colonization dynamics: An ecology approach to quasispecies dynamics and virulence evolution in RNA viruses.Communicative & integrative biology · 2010Article
- Pathways to extinction: beyond the error threshold.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between parasite fitness and virulence has been the object of experimental and theoretical studies often with conflicting conclusions. Here, we provide direct experimental evidence that viral fitness and virulence, both measured in the same biological environment provided by host cells in culture, can be two unrelated traits. A biological clone of foot-and-mouth disease virus acquired high fitness and virulence (cell killing capacity) upon large population passages in cell culture. However, subsequent plaque-to-plaque transfers resulted in profound fitness loss, but only a minimal decrease of virulence. While fitness-decreasing mutations have been mapped throughout the genome, virulence determinants-studied here with mutant and chimeric viruses-were multigenic, but concentrated on some genomic regions. Therefore, we propose a model in which viral virulence is more robust to mutation than viral fitness. As a consequence, depending on the passage regime, viral fitness and virulence can follow different evolutionary trajectories. This lack of correlation is relevant to current models of attenuation and virulence in that virus de-adaptation need not entail a decrease of virulence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.