ReviewJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2007
The diverse and pervasive chemistries of the alpha-keto acid dependent enzymes.
Review in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 80 citations in OpenAlex.
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- Biosynthesis of 14-membered cyclopeptide alkaloids via non-heme-iron- and 2-oxoglutarate-dependent oxidative decarboxylation.bioRxiv : the preprint server for biology · 2026Article
- Spectroscopic definition of ferrous active sites in non-heme iron enzymes.Methods in enzymology · 2024Article
- Biosynthesizing structurally diverse diols via a general route combining oxidative and reductive formations of OH-groups.Nature communications · 2022Article
- A study on the structure, mechanism, and biochemistry of kanamycin B dioxygenase (KanJ)-an enzyme with a broad range of substrates.The FEBS journal · 2021Article
- Article
- Recent examples of α-ketoglutarate-dependent mononuclear non-haem iron enzymes in natural product biosyntheses.Natural product reports · 2018Review
- Copper-Oxygen Complexes Revisited: Structures, Spectroscopy, and Reactivity.Chemical reviews · 2017Review
- Aerobic alcohol oxidation and oxygen atom transfer reactions catalyzed by a nonheme iron(ii)-α-keto acid complex.Chemical science · 2016Article
- Three genes encoding AOP2, a protein involved in aliphatic glucosinolate biosynthesis, are differentially expressed in Brassica rapa.Journal of experimental botany · 2015Article
- De novo sequencing and analysis of Lophophora williamsii transcriptome, and searching for putative genes involved in mescaline biosynthesis.BMC genomics · 2015Article
- Metabolic network capacity of Escherichia coli for Krebs cycle-dependent proline hydroxylation.Microbial cell factories · 2015Article
- Substrate positioning by Gln(239) stimulates turnover in factor inhibiting HIF, an αKG-dependent hydroxylase.Biochemistry · 2014Article
- Crystal structure of a member of a novel family of dioxygenases (PF10014) reveals a conserved cupin fold and active site.Proteins · 2014Article
- Dioxygenases catalyze O-demethylation and O,O-demethylenation with widespread roles in benzylisoquinoline alkaloid metabolism in opium poppy.The Journal of biological chemistry · 2013Article
- Measuring the orientation of taurine in the active site of the non-heme Fe(II)/α-ketoglutarate-dependent taurine hydroxylase (TauD) using electron spin echo envelope modulation (ESEEM) spectroscopy.The journal of physical chemistry. B · 2013Article
- Functional models of α-keto acid dependent nonheme iron oxygenases: synthesis and reactivity of biomimetic iron(II) benzoylformate complexes supported by a 2,9-dimethyl-1,10-phenanthroline ligand.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2013Article
- Activation of α-keto acid-dependent dioxygenases: application of an {FeNO}7/{FeO2}8 methodology for characterizing the initial steps of O2 activation.Journal of the American Chemical Society · 2011Article
- Mechanisms of nickel toxicity in microorganisms.Metallomics : integrated biometal science · 2011Review
- Spectroscopic and computational studies of α-keto acid binding to Dke1: understanding the role of the facial triad and the reactivity of β-diketones.Journal of the American Chemical Society · 2011Article
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2 authors at 1 institution in 1 country.
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Abstract
The number of identified and confirmed alpha-keto acid dependent oxygenases is increasing rapidly. All of these enzymes have a relatively simple liganding arrangement for a single ferrous ion but collectively conduct a highly diverse set of chemistries. While hydroxylations and a variety of oxidation reactions have been most commonly observed, new reactions involving dealkylations, epimerizations and halogenations have recently been discovered. In this minireview we present what is known of the alpha-keto acid dependent enzymes and offer an argument that the chemistry that is unique to each enzyme occurs only after the production of a pivotal ferryl-oxo intermediate.
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