ArticleHuman genetics2007
Linkage and association analysis of candidate genes for TB and TNFalpha cytokine expression: evidence for association with IFNGR1, IL-10, and TNF receptor 1 genes.
Article in Human genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 67 citations in OpenAlex.
- BCG induced innate immune response heterogeneity and susceptibility to pediatric tuberculosis.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- REL and BHLHE40 Variants Are Associated with IL-12 and IL-10 Responses and Tuberculosis Risk.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Article
- Association of TLR8 and TLR9 polymorphisms with tuberculosis in a Chinese Han population: a case-control study.BMC infectious diseases · 2018Article
- Polymorphisms of theBioscience reports · 2018Article
- Novel polymorphisms inGlobal health, epidemiology and genomics · 2018Article
- Genomics of human pulmonary tuberculosis: from genes to pathways.Current genetic medicine reports · 2017Article
- Review
- Meta-analysis of host response networks identifies aNPJ systems biology and applications · 2017Article
- Genetic background affects the expansion of macrophage subsets in the lungs of Mycobacterium tuberculosis-infected hosts.Immunology · 2016Article
- The microbiome at the pulmonary alveolar niche and its role in Mycobacterium tuberculosis infection.Tuberculosis (Edinburgh, Scotland) · 2015Review
- The variations of IL-23R are associated with susceptibility and severe clinical forms of pulmonary tuberculosis in Chinese Uygurs.BMC infectious diseases · 2015Article
- Polymorphisms in TICAM2 and IL1B are associated with TB.Genes and immunity · 2015Article
- Host genome polymorphisms and tuberculosis infection: What we have to say?The Egyptian journal of chest diseases and tuberculosis · 2014Article
- Potential association of pulmonary tuberculosis with genetic polymorphisms of toll-like receptor 9 and interferon-gamma in a Chinese population.BMC infectious diseases · 2013Article
- Genetic and shared environmental influences on interferon-γ production in response to Mycobacterium tuberculosis antigens in a Ugandan population.The American journal of tropical medicine and hygiene · 2013Article
- The null distribution of likelihood-ratio statistics in the conditional-logistic linkage model.Frontiers in genetics · 2013Article
- The household contact study design for genetic epidemiological studies of infectious diseases.Frontiers in genetics · 2013Article
- Innate immune gene polymorphisms in tuberculosis.Infection and immunity · 2012Review
- Association of IFNGR2 gene polymorphisms with pulmonary tuberculosis among the Vietnamese.Human genetics · 2012Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
Tuberculosis (TB) is a growing public health threat globally and several studies suggest a role of host genetic susceptibility in increased TB risk. As part of a household contact study in Kampala, Uganda, we have taken a unique approach to the study of genetic susceptibility to TB by developing an intermediate phenotype model for TB susceptibility, analyzing levels of tumor necrosis factor-alpha (TNFalpha) in response to culture filtrate as the phenotype. In the present study, we analyzed candidate genes related to TNFalpha regulation and found that interleukin (IL)-10, interferon-gamma receptor 1 (IFNGR1), and TNFalpha receptor 1 (TNFR1) genes were linked and associated to both TB and TNFalpha. We also show that these associations are with progression to active disease and not susceptibility to latent infection. This is the first report of an association between TB and TNFR1 in a human population and our findings for IL-10 and IFNGR1 replicate previous findings. By observing pleiotropic effects on both phenotypes, we show construct validity of our intermediate phenotype model, which enables the characterization of the role of these genetic polymorphisms on TB pathogenesis. This study further illustrates the utility of such a model for disentangling complex traits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.