ArticleVirchows Archiv : an international journal of pathology2007
Frequency and diagnostic patterns of lymphomas in liver biopsies with respect to the WHO classification.
Article in Virchows Archiv : an international journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 54 citations in OpenAlex.
- Liver Complications Following Treatment of Hematologic Malignancy With Anti-CD22-Calicheamicin (Inotuzumab Ozogamicin).Hepatology (Baltimore, Md.) · 2019Trial
- [Hepatosplenic T-cell lymphoma: important differential diagnosis to a hepatitis].Pathologie (Heidelberg, Germany) · 2026Article
- Atypical Presentation for Adult T-Cell Leukemia/Lymphoma: a Case Report and Short Review of the Literature.Maedica · 2024Article
- An Elusive Diagnosis: Diffuse Large B-Cell Lymphoma Masquerading as Acute Liver Failure with Persistent Lactic Acidosis.The American journal of case reports · 2023Article
- Patterns of Lymphocytic Infiltrates Can Differentiate Feline Hepatic Lymphoma from Lymphocytic Portal Hepatitis.Veterinary sciences · 2023Article
- Aggressive behaviour of Hodgkin's-like lymphoma in a domestic ferret.Veterinarni medicina · 2021Article
- Vessel co-option in cancer.Nature reviews. Clinical oncology · 2019Review
- Liver dysfunction in chronic lymphocytic leukemia: Prevalence, outcomes, and pathological findings.American journal of hematology · 2017Article
- Non-Hodgkin Lymphoma of the Liver: A US Population-based Analysis.Journal of clinical and translational hepatology · 2017Article
- Diagnosis and differential diagnosis of hepatic graft versus host disease (GVHD).Journal of gastrointestinal oncology · 2016Review
- Focal hepatic uptake along the falciform: False positive for malignancy on 18F-FDG-PET in a lymphoma patient with superior vena cava obstruction.Radiology case reports · 2014Article
- Hepatic reactive lymphoid hyperplasia in a patient with primary biliary cirrhosis.World journal of hepatology · 2010Article
- Simultaneous occurrence of a hepatocellular carcinoma and a hepatic non-Hodgkin's lymphoma infiltration.World journal of hepatology · 2010Article
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8 authors at 3 institutions in 1 country.
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Abstract
The recent World Health Organization (WHO) classification of hematopoietic and lymphoid tissue tumors represents the first worldwide consensus classification of these malignancies. However, the applicability of this classification to a representative number of hepatic lymphomas in liver biopsy specimens has not yet been investigated. The frequency and infiltration pattern of a series of 205 liver biopsies with lymphoma manifestations was analyzed with the aid of immunohistochemical and molecular pathological analyses. Diffuse large B-cell lymphoma (DLBCL) was by far the most frequent entity, comprising 45% of the cases analyzed. Using a previously published immunohistochemical algorithm, 35% of 80 DLBCL were assigned to a germinal center B-cell-like (GCB) and 65% to a non-GCB group. Most B-cell lymphoma entities involving the liver revealed a characteristic infiltration pattern. Diagnostically challenging entities were T-cell-rich B-cell lymphomas, anaplastic large cell lymphomas and peripheral T-cell lymphomas, which frequently required additional molecular clonality assessment. Overall, the percentage of T-cell lymphomas in the liver (12%) was higher as compared to other extranodal sites except for the skin and the small intestine. This study provides relevant data on the distribution of hepatic lymphomas and demonstrates the applicability of the WHO classification proposing a diagnostic algorithm for liver biopsies.
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