Trial reportEnvironmental health perspectives2007
Dental amalgam restorations and children's neuropsychological function: the New England Children's Amalgam Trial.
Trial report in Environmental health perspectives, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Direct composite resin fillings versus amalgam fillings for permanent posterior teeth.The Cochrane database of systematic reviews · 2021Pooled it
- Dental composite restorations and neuropsychological development in children: treatment level analysis from a randomized clinical trial.Neurotoxicology · 2012Trial
- Immune function effects of dental amalgam in children: a randomized clinical trial.Journal of the American Dental Association (1939) · 2008Trial
- Dental amalgam and psychosocial status: the New England Children's Amalgam Trial.Journal of dental research · 2008Trial
- Dental sealants and flowable composite restorations and psychosocial, neuropsychological, and physical development in children.Pediatric dentistryTrial
- Survival Rates of Amalgam and Composite Resin Restorations from Big Data Real-Life Databases in the Era of Restricted Dental Mercury Use.Bioengineering (Basel, Switzerland) · 2024Article
- A framework for assessing the impact of chemical exposures on neurodevelopment in ECHO: Opportunities and challenges.Environmental research · 2020Review
- Clinical Effects of Mercury in Conservative Dentistry: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis of Randomized Controlled Trials.International journal of dentistry · 2020Review
- Determination of Highly Sensitive Biological Cell Model Systems to Screen BPA-Related Health Hazards Using Pathway Studio.International journal of molecular sciences · 2017Article
- Severe dermatitis might be caused by a cross-reaction between nickel and palladium and dental amalgam resolved following removal of dental restorations.Clinical case reports · 2017Article
- Sources of Mercury Exposure to Children in Low- and Middle-Income Countries.Journal of health & pollution · 2015Review
- Reliance on social security benefits by Swedish patients with ill-health attributed to dental fillings: a register-based cohort study.BMC public health · 2012Article
- The dental amalgam toxicity fear: a myth or actuality.Toxicology international · 2012Article
- Changes in health complaints after removal of amalgam fillings.Journal of oral rehabilitation · 2011Article
- Mercury exposure and children's health.Current problems in pediatric and adolescent health care · 2010Review
- Nephrotoxicity, neurotoxicity, and mercury exposure among children with and without dental amalgam fillings.International journal of hygiene and environmental health · 2009Article
- Scalp hair and urine mercury content of children in the Northeast United States: the New England Children's Amalgam Trial.Environmental research · 2008Article
- Fish consumption, methylmercury and child neurodevelopment.Current opinion in pediatrics · 2008Review
- Mercury in human brain, blood, muscle and toenails in relation to exposure: an autopsy study.Environmental health : a global access science source · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundA concern persists that children's exposure to mercury vapor from dental amalgams produces neurotoxicity.
objectiveOur goal was to compare the neuropsychological function of children, without prior exposure to dental amalgam, whose caries were repaired using either dental amalgam or mercury-free composite materials.
methodsWe conducted a randomized controlled trial involving 534 6- to 10-year-old urban and rural children who were assessed yearly for 5 years using a battery of tests of intelligence, achievement, language, memory, learning, visual-spatial skills, verbal fluency, fine motor function, problem solving, attention, and executive function.
resultsAlthough the mean urinary mercury concentration was greater among children in the amalgam group than the composite group (0.9 vs. 0.6 microg/g creatinine), few significant differences were found between the test scores of children in the two groups. The differences found were inconsistent in direction. Analyses using two cumulative exposure indices--surface years of amalgam and urinary mercury concentration--produced similar results.
conclusionsExposure to elemental mercury in amalgam at the levels experienced by the children who participated in the trial did not result in significant effects on neuropsychological function within the 5-year follow-up period.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.