Trial reportEnvironmental health perspectives2007
Quality of life and capsaicin sensitivity in patients with airway symptoms induced by chemicals and scents: a longitudinal study.
Trial report in Environmental health perspectives, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 67 citations in OpenAlex.
- Reliability and Validity of the Swedish Version of the Hull Airway Reflux Questionnaire (HARQ-S).Lung · 2016Article
- TRPV1 and TRPM8 in Treatment of Chronic Cough.Pharmaceuticals (Basel, Switzerland) · 2016Review
- Vagal Afferent Innervation of the Airways in Health and Disease.Physiological reviews · 2016Review
- Diagnosis of asthma in primary health care: a pilot study.Journal of allergy · 2014Article
- A study of two generic health-related quality of life questionnaires--Nottingham Health Profile and Short-Form 36 Health Survey--and of coping in patients with sensory hyperreactivity.Health and quality of life outcomes · 2013Article
- Normative data for the chemical sensitivity scale for sensory hyperreactivity: the Västerbotten environmental health study.International archives of occupational and environmental health · 2013Article
- Capsaicin sensitivity in patients with chronic cough- results from a cross-sectional study.Cough (London, England) · 2013Article
- Symptoms induced by environmental irritants and health-related quality of life in patients with chronic cough - A cross-sectional study.Cough (London, England) · 2011Article
- Sensitivity to environmental irritants and quality of life in COPD.International journal of chronic obstructive pulmonary disease · 2011Article
- On the relation between capsaicin sensitivity and responsiveness to CO2: detection sensitivity and event-related brain potentials.International archives of occupational and environmental health · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIt is common in asthma and allergy clinics to see patients presenting with upper and lower airway symptoms that are induced by chemicals and scents and not explained by allergic or asthmatic reactions. Previous studies have shown that these patients often have increased cough sensitivity to inhaled capsaicin; such sensitivity is known to reflect the airway sensory reactivity. The aim of this study was to evaluate the duration of symptoms induced by chemicals and scents and to measure health-related quality of life (HRQL) in patients with chemically induced airway symptoms. We also wished to determine and compare repeatability of the cough response to capsaicin inhalation, and to evaluate the patients' airway sensory reactivity in a long-term perspective.
participantsSeventeen patients with a history of at least 12 months of airway symptoms induced by chemicals and scents were followed over 5 years with repeated questionnaires, measurements of HRQL, and capsaicin inhalation tests.
resultsThe symptoms persisted and did not change significantly over time, and the patients had a reduced HRQL that did not change during the 5-year period. The capsaicin sensitivity was increased at the start of the study, the cough sensitivity was long-lasting, and the repeatability of the capsaicin inhalation test was considered to be good in a long-term perspective.
conclusionsUpper and lower airway symptoms induced by chemicals and scents represent an entity of chronic diseases, different from asthma or chronic obstructive pulmonary disease, with persistent symptoms, a reduced HRQL, and unchanged sensory hyperreactivity.
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