ArticleEnvironmental health perspectives2007
Impact of trivalent arsenicals on selenoprotein synthesis.
Article in Environmental health perspectives, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 53 citations in OpenAlex.
- Gender differences in plasma element concentrations and associations between selenoprotein P and iron metabolism in a community-based cohort study.Scientific reports · 2025Article
- Unraveling the genetics of arsenic toxicity with cellular morphology QTL.PLoS genetics · 2024Article
- Arsenic exposure and increasedRedox biochemistry and chemistry · 2023Article
- Cell morphology QTL reveal gene by environment interactions in a genetically diverse cell population.bioRxiv : the preprint server for biology · 2023Article
- Crosstalk between regulated necrosis and micronutrition, bridged by reactive oxygen species.Frontiers in nutrition · 2022Review
- Selenium and selenoproteins: it's role in regulation of inflammation.Inflammopharmacology · 2020Review
- SILAC-Based Quantitative Proteomic Analysis Unveils Arsenite-Induced Perturbation of Multiple Pathways in Human Skin Fibroblast Cells.Chemical research in toxicology · 2017Article
- Article
- Monomethylarsonous acid inhibited endogenous cholesterol biosynthesis in human skin fibroblasts.Toxicology and applied pharmacology · 2014Article
- Diphenylmethyl selenocyanate attenuates malachite green induced oxidative injury through antioxidation & inhibition of DNA damage in mice.The Indian journal of medical research · 2013Article
- Silibinin ameliorates arsenic induced nephrotoxicity by abrogation of oxidative stress, inflammation and apoptosis in rats.Molecular biology reports · 2012Article
- Exposure to silver nanoparticles inhibits selenoprotein synthesis and the activity of thioredoxin reductase.Environmental health perspectives · 2012Article
- Anticancer activity of metal complexes: involvement of redox processes.Antioxidants & redox signaling · 2011Review
- Impact of smoking and chewing tobacco on arsenic-induced skin lesions.Environmental health perspectives · 2010Article
- Targeting selenium metabolism and selenoproteins: novel avenues for drug discovery.Metallomics : integrated biometal science · 2010Review
- Exposure to monomethylarsonous acid (MMA(III)) leads to altered selenoprotein synthesis in a primary human lung cell model.Toxicology and applied pharmacology · 2009Article
- Arsenic-induced changes in the gene expression of lung epithelial L2 cells: implications in carcinogenesis.BMC genomics · 2008Article
- High affinity selenium uptake in a keratinocyte model.FEBS letters · 2008Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundExposure to arsenic has been associated with development of skin, lung, bladder, liver, and kidney cancer. Recent evidence suggests that an increase in oxidative stress in cells treated with arsenicals represents the molecular mechanism behind arsenic-induced carcinogenesis. Selenium, in the form of selenocysteine, is necessary for the activity of several enzymes with a role in defense against reactive oxygen species. A mutual sparing effect between arsenic and selenium has been shown in animal studies when both metalloids are present in high concentrations.
objectivesTo determine whether changes in selenoprotein synthesis may be an underlying mechanism behind arsenic-induced carcinogenesis, we analyzed the new synthesis of selenoproteins within cells after exposure to inorganic or methylated arsenicals using a human keratinocyte cell model.
resultsAddition of arsenite to culture medium blocked new synthesis of selenoproteins when selenium was present in the form of selenite, and appeared to stimulate the use of serum-derived selenium. Monomethylarsonous acid (MMA(III)) treatment of cells, in contrast, did not block all new synthesis of selenoproteins but did result in an increase in cytosolic thioredoxin reductase (TrxR1) at both the mRNA and protein levels. MMA(III) also reduced the new synthesis of cellular glutatione peroxidase (cGpx) and other smaller selenoproteins. Dimethylarsinous acid (DMA(III)) stimulated selenoprotein synthesis by an as yet unknown mechanism.
conclusionsThese results suggest that arsenite and MMA(III) are key metabolites that trigger higher levels of TrxR1, and both lead to a reduction in the expression of cGpx. Together these effects certainly could lead to carcinogenesis given the knowledge that many cancers have higher levels of TrxR, and reduced Gpx levels will reduce the cell's ability to defend against reactive oxygen species. Based on these results, the impact of the trivalent arsenicals arsenite and MMA(III) on selenoprotein synthesis may indeed represent a potential molecular mechanism for the higher rates of cancer observed in populations exposed to high levels of arsenic.
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Registered trials
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