Trial reportAmerican journal of respiratory and critical care medicine2007
Sex differences in severe pulmonary emphysema.
Trial report in American journal of respiratory and critical care medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
138 citing papers in PubMed, 3 syntheses or guidelines pooled it, 368 citations in OpenAlex.
- Equity in pulmonary rehabilitation delivery: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- The Use of Computed Tomography Densitometry for the Assessment of Emphysema in Clinical Trials: A Position Paper from the Fleischner Society.American journal of respiratory and critical care medicine · 2025Pooled it
- CT densitometry in emphysema: a systematic review of its clinical utility.International journal of chronic obstructive pulmonary disease · 2018Pooled it
- Induction of dynamic hyperinflation by expiratory resistance breathing in healthy subjects - an efficacy and safety study.Experimental physiology · 2021Trial
- Responsiveness to Ipratropium Bromide in Male and Female Patients with Mild to Moderate Chronic Obstructive Pulmonary Disease.EBioMedicine · 2017Trial
- Association of biomarkers of inflammation and cell adhesion with lung function in the elderly: a population-based study.BMC geriatrics · 2013Trial
- Anxiety is associated with diminished exercise performance and quality of life in severe emphysema: a cross-sectional study.Respiratory research · 2010Trial
- Emphysema or Bronchiectasis with Pulmonary Nodules: Impact on The Risk of Malignancy.Thoracic research and practice · 2026Article
- Trends in mortality with chronic obstructive pulmonary disease as the underlying cause and chronic kidney disease as a contributing cause among US adults, 1999-2020: a CDC WONDER analysis.BMC pulmonary medicine · 2026Observational
- Sexually distinct multi-omic responses to progressive endurance exercise training in the rat lung.American journal of respiratory cell and molecular biology · 2026Article
- Sex differences among inpatients with AECOPD in a tertiary hospital during the COVID-19 pandemic.BMC pulmonary medicine · 2026Article
- Sex-Specific Plasma Metabolomic Signatures in COPD Reveal Creatine, Purine/Urate, and Bile-Acid Axes.Metabolites · 2026Article
- Sex, hormones, and lung health.Physiological reviews · 2026Review
- The importance of mechanical forces in chronic respiratory diseases.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Chronic Obstructive Pulmonary Disease and Depression-The Vicious Mental Cycle.Healthcare (Basel, Switzerland) · 2025Review
- Gender-stratified analyses of symptoms associated with life-threatening events in patients calling out-of-hours primary care for shortness of breath.BMC primary care · 2025Article
- Gender, tobacco and chronic obstructive pulmonary disease: analysis of the 2020 National Health Interview Survey.BMJ open respiratory research · 2025Article
- Sex Differences in Chronic Obstructive Pulmonary Disease: Implications for Pathogenesis, Diagnosis, and Treatment.International journal of molecular sciences · 2025Review
- Sex-differences in the multidimensional evaluation of dyspnea in respiratory outpatients.Frontiers in medicine · 2025Article
- Exploring the role of sex in asthma and COPD pharmacological treatment.Current research in pharmacology and drug discovery · 2025Review
78 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
19 authors at 11 institutions in 2 countries.
Funding
Abstract
rationaleLimited data on sex differences in advanced COPD are available.
objectivesTo compare male and female emphysema patients with severe disease.
methodsOne thousand fifty-three patients (38.8% female) evaluated for lung volume reduction surgery as part of the National Emphysema Treatment Trial were analyzed. MEASUREMENTS AND MAIN
resultsDetailed clinical, physiological, and radiological assessment, including quantitation of emphysema severity and distribution from helical chest computed tomography, was completed. In a subgroup (n = 101), airway size and thickness was determined by histological analyses of resected tissue. Women were younger and exhibited a lower body mass index (BMI), shorter smoking history, less severe airflow obstruction, lower Dl(co) and arterial Po(2), higher arterial Pco(2), shorter six-minute walk distance, and lower maximal wattage during oxygen-supplemented cycle ergometry. For a given FEV(1)% predicted, age, number of pack-years, and proportion of emphysema, women experienced greater dyspnea, higher modified BODE, more depression, lower SF-36 mental component score, and lower quality of well-being. Overall emphysema was less severe in women, with the difference from men most evident in the outer peel of the lung. Females had thicker small airway walls relative to luminal perimeters.
conclusionsIn patients with severe COPD, women, relative to men, exhibit anatomically smaller airway lumens with disproportionately thicker airway walls, and emphysema that is less extensive and characterized by smaller hole size and less peripheral involvement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.