ArticleAmerican journal of respiratory and critical care medicine2007
Bubble continuous positive airway pressure enhances lung volume and gas exchange in preterm lambs.
Article in American journal of respiratory and critical care medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 152 citations in OpenAlex.
- Continuous positive airway pressure (CPAP) for apnoea of prematurity.The Cochrane database of systematic reviews · 2023Pooled it
- Nebulized salbutamol for the treatment of transient tachypnea of the newborn: a randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2025Trial
- RAM cannula versus short binasal prongs for nasal continuous positive airway pressure delivery in preterm infants: a randomized, noninferiority trial from low-middle-income country.European journal of pediatrics · 2022Trial
- Trial
- Bubble vs conventional continuous positive airway pressure for prevention of extubation failure in preterm very low birth weight infants: a pilot study.Indian journal of pediatrics · 2012Trial
- Bubble and ventilator-derived nasal continuous positive airway pressure in premature infants: work of breathing and gas exchange.Journal of perinatology : official journal of the California Perinatal Association · 2011Trial
- Comparison of nasal interfaces and pressures during critical time-points in NICU: observation data from over 10 years.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Effects of a respiratory care protocol incorporating less invasive surfactant administration in infants born at 30-34 weeks' gestation.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Respiratory distress syndrome is the poster child for neonatology.Pediatric research · 2025Article
- Bubble devices versus other pressure sources for nasal continuous positive airway pressure in preterm infants.The Cochrane database of systematic reviews · 2023Review
- Performance Characteristics of a Novel 3D-Printed Bubble Intermittent Mandatory Ventilator (B-IMV) for Adult Pulmonary Support.Bioengineering (Basel, Switzerland) · 2022Article
- Duration of noninvasive respiratory support and risk for bronchopulmonary dysplasia or death.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Time to Lung Volume Stability After Pressure Change During High-Frequency Oscillatory Ventilation.Critical care explorations · 2021Article
- A Quality Improvement Initiative to Reduce Bronchopulmonary Dysplasia in a Level 4 NICU-Golden Hour Management of Respiratory Distress Syndrome in Preterm Newborns.Children (Basel, Switzerland) · 2021Article
- Non-invasive Respiratory Support of the Premature Neonate: From Physics to Bench to Practice.Frontiers in pediatrics · 2020Review
- Bronchopulmonary dysplasia.Nature reviews. Disease primers · 2019Review
- High amplitude bubble continuous positive airway pressure decreases lung injury in rats with ventilator-induced lung injury.Journal of the Chinese Medical Association : JCMA · 2019Article
- Article
- Pediatric Respiratory Support Technology and Practices: A Global Survey.Healthcare (Basel, Switzerland) · 2017Article
- An authentic animal model of the very preterm infant on nasal continuous positive airway pressure.Intensive care medicine experimental · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
rationaleThe technique used to provide continuous positive airway pressure (CPAP) to the newborn may influence lung function and breathing efficiency.
objectivesTo compare differences in gas exchange physiology and lung injury resulting from treatment of respiratory distress with either bubble or constant pressure CPAP and to determine if the applied flow influences short-term outcomes.
methodsLambs (133 d gestation; term is 150 d) born via cesarean section were weighed, intubated, and treated with CPAP for 3 hours. Two groups were treated with 8 L/minute applied flow using the bubble (n = 12) or the constant pressure (n = 12) technique. A third group (n = 10) received the bubble method with 12 L/minute bias flow. Measurements at study completion included arterial blood gases, oxygraphy, capnography, tidal flow, multiple breath washout, lung mechanics, static pressure-volume curves, and bronchoalveolar lavage fluid protein. MEASUREMENTS AND MAIN
resultsBirth weight and arterial gas variables at 15 minutes were comparable. Flow (8 or 12 L/min) did not influence the 3-hour outcomes in the bubble group. Bubble technique was associated with a higher pH, Pa(O2), oxygen uptake, and area under the flow-volume curve, and a decreased alveolar protein, respiratory quotient, Pa(CO2), and ventilation inhomogeneity compared with the constant pressure group.
conclusionsCompared with constant pressure technique, bubble CPAP promotes enhanced airway patency during treatment of acute postnatal respiratory disease in preterm lambs and may offer protection against lung injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.