ArticleScience (New York, N.Y.)2007
Protein sequences from mastodon and Tyrannosaurus rex revealed by mass spectrometry.
Article in Science (New York, N.Y.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
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Who cites it
78 citing papers in PubMed, 314 citations in OpenAlex.
- Molecular Paleontology Meets Drug Discovery: The Case for De-extinct Antimicrobials.ACS omega · 2025Review
- Preserving Fossilized Soft Tissues: Advancing Proteomics and Unveiling the Evolutionary History of Cancer in Dinosaurs.Biology · 2025Article
- Fossilized dinosaur cells that defied the ravages of time - 20 years since a key discovery.Nature · 2025Article
- Evidence for Endogenous Collagen inAnalytical chemistry · 2025Article
- Age is just a number: Examining the preservation of cells and soft tissues in Bothriolepis and other Devonian fish.PloS one · 2025Article
- Latest Advances in Structural Insights and Quantification Techniques for Type I Collagen Biomarkers: A path toward standardization?Biomarker insights · 2025Review
- Preservation of proteins in the geosphere.Nature ecology & evolution · 2024Review
- Independent Evidence for the Preservation of Endogenous Bone Biochemistry in a Specimen ofBiology · 2023Article
- Biomolecular histology as a novel proxy for ancient DNA and protein sequence preservation.Ecology and evolution · 2022Article
- Paleoproteomics.Chemical reviews · 2022Review
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- Biofinder detects biological remains in Green River fish fossils from Eocene epoch at video speed.Scientific reports · 2022Article
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- Abnormal (Hydroxy)proline Deuterium Content Redefines Hydrogen Chemical Mass.Journal of the American Chemical Society · 2022Article
- The quest for a generic bird target to detect the presence of bird in food products and considerations for paleoprotein analysis.PloS one · 2022Article
- Comprehensive Metabolic and Taxonomic Reconstruction of an Ancient Microbial Mat From the McMurdo Ice Shelf (Antarctica) by Integrating Genetic, Metaproteomic and Lipid Biomarker Analyses.Frontiers in microbiology · 2022Article
- Article
18 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fossilized bones from extinct taxa harbor the potential for obtaining protein or DNA sequences that could reveal evolutionary links to extant species. We used mass spectrometry to obtain protein sequences from bones of a 160,000- to 600,000-year-old extinct mastodon (Mammut americanum) and a 68-million-year-old dinosaur (Tyrannosaurus rex). The presence of T. rex sequences indicates that their peptide bonds were remarkably stable. Mass spectrometry can thus be used to determine unique sequences from ancient organisms from peptide fragmentation patterns, a valuable tool to study the evolution and adaptation of ancient taxa from which genomic sequences are unlikely to be obtained.
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