ArticleAmerican journal of epidemiology2007
Transitions to mild cognitive impairments, dementia, and death: findings from the Nun Study.
Article in American journal of epidemiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04382963 (Stroke Prevention in the Wisconsin Native American Population), which is not on this map. Cited by 72 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Stroke Prevention in the Wisconsin Native American Population
Who cites it
72 citing papers in PubMed, 164 citations in OpenAlex.
- A multistate model of cognitive dynamics in relation to resistance training: the contribution of baseline function.Annals of epidemiology · 2013Trial
- Preventing cognitive decline in older African Americans with mild cognitive impairment: design and methods of a randomized clinical trial.Contemporary clinical trials · 2012Trial
- The Nun Study: Insights from 30 years of aging and dementia research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Finite Markov chains with absorbing states and mis-specified random effects: application to cognitive data.Biostatistics & epidemiology · 2025Article
- Pure LATE-NC: Frequency, clinical impact, and the importance of considering APOE genotype when assessing this and other subtypes of non-Alzheimer's pathologies.Acta neuropathologica · 2024Article
- Socioeconomic inequalities linked to the transitioning to neurocognitive disorders and mortality.Scientific reports · 2024Article
- Intersectional Effects of Race and Educational Attainment on Memory Function of Middle-Aged and Older Adults With Alzheimer's Disease.Journal of racial and ethnic health disparities · 2024Article
- Estimating random effects in a finite Markov chain with absorbing states: Application to cognitive data.Statistica Neerlandica · 2023Article
- Transcranial Magnetic Stimulation Improves Executive Functioning through Modulation of Social Cognitive Networks in Patients with Mild Cognitive Impairment: Preliminary Results.Diagnostics (Basel, Switzerland) · 2023Article
- A Promising Strategy to Treat Neurodegenerative Diseases by SIRT3 Activation.International journal of molecular sciences · 2023Review
- Article
- Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts.Acta neuropathologica · 2022Article
- Cognitive Reserve and Mild Cognitive Impairment: Predictors and Rates of Reversion to Intact Cognition vs Progression to Dementia.Neurology · 2022Article
- Risk of conversion from mild cognitive impairment to dementia in low- and middle-income countries: A systematic review and meta-analysis.Alzheimer's & dementia (New York, N. Y.) · 2022Review
- Associations and correlates of general versus specific successful ageing components.European journal of ageing · 2021Article
- Oestrogen treatment modulates the impact of cognitive experience and task complexity on memory in middle-aged surgically menopausal rats.Journal of neuroendocrinology · 2021Article
- Trends in functional disability and cognitive impairment among the older adult in China up to 2060: estimates from a dynamic multi-state population model.BMC geriatrics · 2021Article
- Reduced rank multinomial logistic regression in Markov chains with application to cognitive data.Statistics in medicine · 2021Article
- Childhood infectious diseases and old age cognitive functioning: a nationally representative sample of community-dwelling older adults.International psychogeriatrics · 2021Article
- A multivariate model of time to conversion from mild cognitive impairment to Alzheimer's disease.GeroScience · 2020Article
12 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
The potential of early interventions for dementia has increased interest in cognitive impairments less severe than dementia. However, predictors of the trajectory from intact cognition to dementia have not yet been clearly identified. The purpose of this study was to determine whether known risk factors for dementia increased the risk of mild cognitive impairments or progression from mild cognitive impairments to dementia. A polytomous logistic regression model was used, with parameters governing transitions within transient states (intact cognition, mild cognitive impairments, global impairment) estimated separately from parameters governing the transition from transient to absorbing state (dementia or death). Analyses were based on seven annual examinations (1991-2002) of 470 Nun Study participants aged > or = 75 years at baseline and living in the United States. Odds of developing dementia increased with age primarily for those with low educational levels. In these women, presence of an apolipoprotein E gene *E4 allele increased the odds more than fourfold by age 95 years. Age, education, and the apolipoprotein E gene were all significantly associated with mild cognitive impairments. Only age, however, was associated with progression to dementia. Thus, risk factors for dementia may operate primarily by predisposing individuals to develop mild cognitive impairments; subsequent progression to dementia then depends on only time and competing mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.