ArticleNucleic acids research2007
Investigation of spectral conversion of d(TTAGGG)4 and d(TTAGGG)13 upon potassium titration by a G-quadruplex recognizer BMVC molecule.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 84 citations in OpenAlex.
- Selective Recognition ofACS medicinal chemistry letters · 2024Article
- Thermally Induced Transitions of d(GLife (Basel, Switzerland) · 2022Article
- Parallel folding topology-selective label-free detection and monitoring of conformational and topological changes of different G-quadruplex DNAs by emission spectral changesChemical science · 2016Article
- Structural basis of sodium-potassium exchange of a human telomeric DNA quadruplex without topological conversion.Nucleic acids research · 2014Article
- In-cell optical imaging of exogenous G-quadruplex DNA by fluorogenic ligands.Nucleic acids research · 2013Article
- Evaluation of the interaction between long telomeric DNA and macrocyclic hexaoxazole (6OTD) dimer of a G-quadruplex ligand.Molecules (Basel, Switzerland) · 2013Article
- A dual-site simultaneous binding mode in the interaction between parallel-stranded G-quadruplex [d(TGGGGT)]4 and cyanine dye 2,2'-diethyl-9-methyl-selenacarbocyanine bromide.Nucleic acids research · 2013Article
- Kinetic partitioning modulates human telomere DNA G-quadruplex structural polymorphism.PloS one · 2013Article
- Polymorphism of human telomeric quadruplex structure controlled by DNA concentration: a Raman study.Nucleic acids research · 2013Article
- Molecular engineering of G-quadruplex ligands based on solvent effect of polyethylene glycol.Nucleic acids research · 2012Article
- Article
- Interactions of a platinum-modified perylene derivative with the human telomeric G-quadruplex.The journal of physical chemistry. B · 2011Article
- Emulsified BMVC derivative induced filtration for G-quadruplex DNA structural separation.Nucleic acids research · 2011Article
- Single molecule studies of physiologically relevant telomeric tails reveal POT1 mechanism for promoting G-quadruplex unfolding.The Journal of biological chemistry · 2011Article
- Kinetically governed polymorphism of d(G₄T₄G₃) quadruplexes in K+ solutions.Nucleic acids research · 2011Article
- Single-molecule TPM studies on the conversion of human telomeric DNA.Biophysical journal · 2010Article
- Structural insights into G-quadruplexes: towards new anticancer drugs.Future medicinal chemistry · 2010Review
- Arrangements of human telomere DNA quadruplex in physiologically relevant K+ solutions.Nucleic acids research · 2009Article
- Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates.Organic & biomolecular chemistry · 2009Article
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5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
We have introduced a G-quadruplex-binding ligand, 3,6-bis(1-methyl-4-vinylpyridinium)carbazole diiodide (BMVC), to verify the major structure of d(T2AG3)4 (H24) in potassium solution and examine the structural conversion of H24 in sodium solution upon potassium titration. The studies of circular dichroism, induced circular dichroism, spectral titration and gel competition have allowed us to determine the binding mode and binding ratio of BMVC to the H24 in solution and eliminate the parallel form as the major G-quadruplex structure. Although the mixed-type form could not be eliminated as a main component, the basket and chair forms are more likely the main components of H24 in potassium solution. In addition, the circular dichroism spectra and the job plots reveal that a longer telomeric sequence d(T2AG3)13 (H78) could form two units of G4 structure both in sodium or potassium solutions. Of particular interest is that no appreciable change on the induced circular dichroism spectra of BMVC is found during the change of the circular dichroism patterns of H24 upon potassium titration. Considering similar spectral conversion detected for H24 and a long sequence H78 together with the G4 structure stabilized by BMVC, it is therefore unlikely that the rapid spectral conversion of H24 and H78 is due to structural change between different types of the G4 structures. With reference to the circular dichroism spectra of d(GAA)7 and d(GAAA)5, we suggest that the spectral conversion of H24 upon potassium titration is attributed to fast ion exchange resulting in different loop base interaction and various hydrogen bonding effects.
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