ArticleBMC genetics2007
Genetic fixity in the human major histocompatibility complex and block size diversity in the class I region including HLA-E.
Article in BMC genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Review
- The Path to Conserved Extended Haplotypes: Megabase-Length Haplotypes at High Population Frequency.Frontiers in genetics · 2021Review
- Diversity of HLA Class I and Class II blocks and conserved extended haplotypes in Lacandon Mayans.Scientific reports · 2020Article
- SNP-Density Crossover Maps of Polymorphic Transposable Elements and HLA Genes Within MHC Class I Haplotype Blocks and Junction.Frontiers in genetics · 2020Article
- Article
- Novel HLA class I associations with HIV-1 control in a unique genetically admixed population.Scientific reports · 2018Article
- Complete haplotype phasing of the MHC and KIR loci with targeted HaploSeq.BMC genomics · 2015Article
- HLA Allele E*01:01 Is Associated with a Reduced Risk of EBV-Related Classical Hodgkin Lymphoma Independently of HLA-A*01/*02.PloS one · 2015Article
- Dominant sequences of human major histocompatibility complex conserved extended haplotypes from HLA-DQA2 to DAXX.PLoS genetics · 2014Article
- Congruence as a measurement of extended haplotype structure across the genome.Journal of translational medicine · 2012Article
- Human leukocyte antigens and HIV type 1 viral load in early and chronic infection: predominance of evolving relationships.PloS one · 2010Article
- Defining multiple common "completely" conserved major histocompatibility complex SNP haplotypes.Clinical immunology (Orlando, Fla.) · 2009Article
- The frequent and conserved DR3-B8-A1 extended haplotype confers less diabetes risk than other DR3 haplotypes.Diabetes, obesity & metabolism · 2009Article
- Extreme genetic risk for type 1A diabetes in the post-genome era.Journal of autoimmunity · 2008Review
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
backgroundThe definition of human MHC class I haplotypes through association of HLA-A, HLA-Cw and HLA-B has been used to analyze ethnicity, population migrations and disease association.
resultsHere, we present HLA-E allele haplotype association and population linkage disequilibrium (LD) analysis within the ~1.3 Mb bounded by HLA-B/Cw and HLA-A to increase the resolution of identified class I haplotypes. Through local breakdown of LD, we inferred ancestral recombination points both upstream and downstream of HLA-E contributing to alternative block structures within previously identified haplotypes. Through single nucleotide polymorphism (SNP) analysis of the MHC region, we also confirmed the essential genetic fixity, previously inferred by MHC allele analysis, of three conserved extended haplotypes (CEHs), and we demonstrated that commercially-available SNP analysis can be used in the MHC to help define CEHs and CEH fragments.
conclusionWe conclude that to generate high-resolution maps for relating MHC haplotypes to disease susceptibility, both SNP and MHC allele analysis must be conducted as complementary techniques.
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