ArticleEuropean journal of immunology2007
CD59a deficiency exacerbates influenza-induced lung inflammation through complement-dependent and -independent mechanisms.
Article in European journal of immunology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Human axillary lymph node T follicular helper (Tfh) and Precursor-Tfh cells exhibit functional flexibility following seasonal influenza vaccination.Clinical & translational immunology · 2025Article
- Emerging role of complement in COVID-19 and other respiratory virus diseases.Cellular and molecular life sciences : CMLS · 2024Review
- Activation of NR1H3 attenuates the severity of septic myocardial injury by inhibiting NLRP3 inflammasome.Bioengineering & translational medicine · 2023Article
- A Biological Insight into the Susceptibility to Influenza Infection in Junior Rats by Comprehensive Analysis of lncRNA Profiles.BioMed research international · 2021Article
- Oral Fucoidan Attenuates Lung Pathology and Clinical Signs in a Severe Influenza a Mouse Model.Marine drugs · 2020Article
- Review
- CD206+ cell number differentiates influenza A (H1N1)pdm09 from seasonal influenza A virus in fatal cases.Mediators of inflammation · 2014Article
- Interleukin-6 limits influenza-induced inflammation and protects against fatal lung pathology.European journal of immunology · 2013Article
- Complement C5 activation during influenza A infection in mice contributes to neutrophil recruitment and lung injury.PloS one · 2013Article
- Influenza virus specific CD8⁺ T cells exacerbate infection following high dose influenza challenge of aged mice.BioMed research international · 2013Article
- Absence of CD59 exacerbates systemic autoimmunity in MRL/lpr mice.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Airway epithelial cells condition dendritic cells to express multiple immune surveillance genes.PloS one · 2012Article
- The protective role of CD59 and pathogenic role of complement in hepatic ischemia and reperfusion injury.The American journal of pathology · 2011Article
- Article
- Analysis of the proteome of human airway epithelial secretions.Proteome science · 2011Article
- Genomic profiling of tumor necrosis factor alpha (TNF-alpha) receptor and interleukin-1 receptor knockout mice reveals a link between TNF-alpha signaling and increased severity of 1918 pandemic influenza virus infection.Journal of virology · 2010Article
- Complement regulator CD59 protects against angiotensin II-induced abdominal aortic aneurysms in mice.Circulation · 2010Article
- A new therapeutic strategy for lung tissue injury induced by influenza with CR2 targeting complement inhibitor.Virology journal · 2010Article
- CD59 blockade enhances antigen-specific CD4+ T cell responses in humans: a new target for cancer immunotherapy?Journal of immunology (Baltimore, Md. : 1950) · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Influenza-specific immune activity not only promotes virus clearance but also causes immunopathology, thereby underlining the importance of mounting a measured anti-viral immune response. Since complement bridges both the innate and adaptive immune systems and has been implicated in defence against influenza, the role of the complement regulator CD59a in modulating the response to influenza was explored. For this purpose, immune responses to influenza virus, strain E61-13-H17, in mice deficient in the complement regulator protein CD59a (Cd59a(-/-) mice) were compared to those in wild-type mice. The severity of lung inflammation was significantly enhanced in the lungs of Cd59a(-/-) mice with increased numbers of infiltrating neutrophils and CD4(+) T cells. When complement was inhibited using soluble complement receptor 1, the frequency of lung-infiltrating neutrophils in influenza-infected Cd59a(-/-) mice was much reduced whilst numbers of CD4(+) T cells remained unchanged. These results demonstrate that CD59a, previously defined as a complement regulator, modulates both the innate and adaptive immune response to influenza virus by both complement-dependent and -independent mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.