Trial reportDigestive diseases and sciences2007
Prospective, randomized trial comparing effect of oral versus intravenous pantoprazole on rebleeding after nonvariceal upper gastrointestinal bleeding: a pilot study.
Trial report in Digestive diseases and sciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Proton pump inhibitor treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleeding.The Cochrane database of systematic reviews · 2022Pooled it
- Oral Proton Pump Inhibitors May Be as Effective as Intravenous in Peptic Ulcer Bleeding: A Systematic Review and Meta-analysis.Clinical and translational gastroenterology · 2021Pooled it
- High-dose vs. Low-dose Proton Pump Inhibitors post-endoscopic hemostasis in patients with bleeding peptic ulcer. A meta-analysis and meta-regression analysis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2018Pooled it
- Comparing intravenous and oral proton pump inhibitor therapy for bleeding peptic ulcers following endoscopic management: a systematic review and meta-analysis.British journal of clinical pharmacology · 2017Pooled it
- Is the era of intravenous proton pump inhibitors coming to an end in patients with bleeding peptic ulcers? Meta-analysis of the published literature.British journal of clinical pharmacology · 2016Pooled it
- Comparison of different regimens of proton pump inhibitors for acute peptic ulcer bleeding.The Cochrane database of systematic reviews · 2013Pooled it
- Proton pump inhibitor treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleeding.The Cochrane database of systematic reviews · 2010Pooled it
- High-dose vs low-dose proton pump inhibitors for upper gastrointestinal bleeding: a meta-analysis.World journal of gastroenterology · 2010Pooled it
- Oral versus intravenous proton pump inhibitors in preventing re-bleeding for patients with peptic ulcer bleeding after successful endoscopic therapy.BMC gastroenterology · 2012Trial
- Effect of high-dose oral rabeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.Gastroenterology research and practice · 2012Article
- Pantoprazole for the treatment of peptic ulcer bleeding and prevention of rebleeding.Clinical medicine insights. Gastroenterology · 2012Review
- Comparison of oral and intravenous proton pump inhibitor on patients with high risk bleeding peptic ulcers: a prospective, randomized, controlled clinical trial.Iranian Red Crescent medical journal · 2011Article
- How evidence-based are current guidelines for managing patients with peptic ulcer bleeding?World journal of gastrointestinal surgery · 2010Article
- A clinical guide to using intravenous proton-pump inhibitors in reflux and peptic ulcers.Therapeutic advances in gastroenterology · 2010Article
- Gastric acid inhibition in the treatment of peptic ulcer hemorrhage.Current gastroenterology reports · 2009Review
- Management of upper gastrointestinal bleeding.Current gastroenterology reports · 2008Review
- Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proton pump inhibitors (PPIs) reduce the rate of rebleeding in patients with nonvariceal upper GI bleed (NVGIB). Oral (PO) and intravenous (IV) pantoprazole are equipotent in raising gastric pH. We conducted a pilot study comparing the efficacy of PO vs. IV pantoprazole for reducing rebleeding after NVGIB. Patients with NVGIB were randomized to receive PO (80 mg BID for 3 days) or IV (80-mg IV bolus and 8 mg/hr infusion for 3 days) pantoprazole followed by pantoprazole, 40 mg PO BID, for 30 days. All patients underwent endoscopy within 24 hr and endotherapy was applied where necessary. Twelve patients randomized to the PO and 13 to the IV pantoprazole group were comparable in age, hematocrit, Rockall scores, ulcer characteristics, and endoscopic interventions. Two patients in the IV arm rebled and another in the IV arm developed reversible renal failure. No patient in the PO arm rebled, had organ failure, or had to be changed to IV pantoprazole. We conclude that in this pilot study, the effect of PO pantoprazole on 30-day rebleeding rate in patients with NVGIB was similar to that of IV pantoprazole.
Indexed as
Identifiers
17429726What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.