ArticleMedical microbiology and immunology2007
Pathogenesis of leptospirosis: interaction of Leptospira interrogans with in vitro cultured mammalian cells.
Article in Medical microbiology and immunology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 39 citations in OpenAlex.
- Internalization of Leptospira interrogans via diverse endocytosis mechanisms in human macrophages and vascular endothelial cells.PLoS neglected tropical diseases · 2022Article
- Alive Pathogenic and Saprophytic Leptospires Enter and Exit Human and Mouse Macrophages With No Intracellular Replication.Frontiers in cellular and infection microbiology · 2022Article
- Leptospiral Infection, Pathogenesis and Its Diagnosis-A Review.Pathogens (Basel, Switzerland) · 2021Review
- Leptospirosis is an invasive infectious and systemic inflammatory disease.Biomedical journal · 2020Review
- Phagocyte Escape ofFrontiers in immunology · 2020Review
- The role of reactive oxygen intermediates in the intracellular fate of Leptospira interrogans in the macrophages of different hosts.PloS one · 2017Article
- Article
- Establishment of a leptospirosis model in guinea pigs using an epicutaneous inoculations route.BMC infectious diseases · 2012Article
- Leptospira and inflammation.Mediators of inflammation · 2012Article
- Inactivation of the fliY gene encoding a flagellar motor switch protein attenuates mobility and virulence of Leptospira interrogans strain Lai.BMC microbiology · 2009Article
- Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen.Nature reviews. Microbiology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interactions of virulent Leptospira interrogans with murine monocyte-macrophage-like J774A.1 cells and Vero (African green monkey kidney fibroblasts) cells from attachment to internalization were investigated by a series of morphological analysis. Fontana silver staining revealed that only the pathogenic leptospires were able to attach to host cells and the attachment pattern varied depending on cell types that they interacted with. Transmission electron microscopy (TEM) analysis confirmed the formation of the leptospires-containing phagosomes and their colocalization with lysosomes in macrophages were verified by confocal microscopic analysis. Results of F-actin rearrangements examination indicated that virulent leptospires invaded host cells via a microfilament-independent pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.