ArticleVirchows Archiv : an international journal of pathology2007
Expression of nuclear factor kappaB in human gastric carcinoma: relationship with I kappaB a and prognostic significance.
Article in Virchows Archiv : an international journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- NF-κB Expression and Outcomes in Solid Tumors: A Systematic Review and Meta-Analysis.Medicine · 2015Pooled it
- HER2, NF-Disease markers · 2019Article
- Primary High-Grade Non-Muscle-Invasive Bladder Cancer: High NFκB Expression in Tumor Specimens Distinguishes Patients Who are at Risk for Disease Progression.Pathology oncology research : POR · 2019Article
- Triptolide Combined with Radiotherapy for the Treatment of Nasopharyngeal Carcinoma via NF-κB-Related Mechanism.International journal of molecular sciences · 2016Article
- Inhibition of PHLPP2/cyclin D1 protein translation contributes to the tumor suppressive effect of NFκB2 (p100).Oncotarget · 2016Article
- Epigenetic Upregulation of Metallothionein 2A by Diallyl Trisulfide Enhances Chemosensitivity of Human Gastric Cancer Cells to Docetaxel Through Attenuating NF-κB Activation.Antioxidants & redox signaling · 2016Article
- Nuclear factor kappa B role in inflammation associated gastrointestinal malignancies.World journal of gastroenterology · 2015Review
- Targeting apoptosis pathways in cancer with alantolactone and isoalantolactone.TheScientificWorldJournal · 2013Review
- Clinicopathologic significance of expression of nuclear factor-κB RelA and its target gene products in gastric cancer patients.World journal of gastroenterology · 2012Article
- Inflammation and cancer.World journal of gastrointestinal surgery · 2012Article
- Effect of RNAi-induced down regulation of nuclear factor kappa-B p65 on acute monocytic leukemia THP-1 cells in vitro and vivo.Molecular and cellular biochemistry · 2012Article
- Molecular marker identification for relapse prediction in 5-FU-based adjuvant chemotherapy in gastric and colorectal cancers.PloS one · 2012Article
- Curcumin attenuates gastric cancer induced by N-methyl-N-nitrosourea and saturated sodium chloride in rats.Journal of biomedicine & biotechnology · 2012Article
- Characterization of apoptosis and proliferation in esophageal carcinoma EC109 cells following siRNA-induced down-regulation of TRAF6.Molecular and cellular biochemistry · 2011Article
- Nuclear factor-κB expression is predictive of overall survival in patients with cutaneous melanoma.Oncology letters · 2010Article
- Nature meets nurture: molecular genetics of gastric cancer.Human genetics · 2009Review
- Inflammation and cancer: how friendly is the relationship for cancer patients?Current opinion in pharmacology · 2009Review
- NF-KappaB expression correlates with apoptosis and angiogenesis in clear cell renal cell carcinoma tissues.Journal of experimental & clinical cancer research : CR · 2008Article
- Clinical significance of nuclear factor (NF)-kappaB levels in urothelial carcinoma of the urinary bladder.Virchows Archiv : an international journal of pathology · 2008Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nuclear factor (NF)-kappaB is a transcription factor constitutively activated in various neoplasms, including gastric carcinoma. However, its clinical significance in the latter remains an unresolved issue, as published information is limited and controversial. Furthermore, no data is available about the interaction of NF kappaB with its inhibitory protein I kappaB a in gastric carcinoma cases. In this study, the expression of NF kappaB 1/p50 and p I kappaB a protein was evaluated immunohistochemically in paraffin-embedded tissues from 93 patients. The effect of NF kappaB 1/p50 and p I kappaB a on clinical outcome was assessed. Positive immunostaining was detected for nuclear NF kappaB 1/p50, cytoplasmic NF kappa B1/p50 and p I kappaB a in 91, 68 and 85.7% of cases, respectively. A positive correlation emerged between nuclear NF kappa B 1/p50 and p I kappaB a (p < 0.0001) and a negative one between cytoplasmic NF kappaB 1/p50 and p I kappaB a (p = 0.0033). Nuclear NF kappaB 1/p50 was associated with stage (p = 0.0388), the depth of invasion (p = 0.0382), World Health Organization (WHO; p = 0.0326) and Lauren's histological classification (p = 0.0046). NF kappaB 1/p50 nuclear expression adversely affected survival in both univariate and multivariate analysis (p < 0.0001 and p = 0.02, respectively). Our results suggest that NF kappaB 1/p50 nuclear expression and therefore activation is regulated by its interaction with I kappaB a and that the former may serve as a useful independent molecular marker for stratifying patients with gastric carcinoma in terms of prognosis.
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