Evidence map›Paper›PMID 17429603›Full record

ArticleDiabetologia2007

TCF7L2 in the Go-DARTS study: evidence for a gene dose effect on both diabetes susceptibility and control of glucose levels.

C H Kimber, A S F Doney, E R Pearson, M I McCarthy, A T Hattersley, G P Leese, A D Morris, C N A Palmer

Registry-linked trialOpen access · bronzeAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Diabetologia, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02783469 (Genetics of Diabetes Audit and Research in Tayside Scotland), which is not on this map. Cited by 31 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 4 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02783469 completednot on this map

Genetics of Diabetes Audit and Research in Tayside Scotland (DOLORisk Dundee)

TypeobservationalSponsorUniversity of DundeeRan2004 to 2009Enrolled1,915ConditionsDiabetic Neuropathic PainArmsIdentification of genetic causes of diabetic neuropathic pain
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 87 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Association of rs12255372 in the TCF7L2 gene with type 2 diabetes mellitus: a meta-analysis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2013
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  10. Costs and Treatment Pathways for Type 2 Diabetes in the UK: A Mastermind Cohort Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2017
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  12. Review
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  14. Association of TCF7L2 Genetic Polymorphisms with Type 2 Diabetes Mellitus in the Uygur Population of China.International journal of environmental research and public health · 2015
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  17. Pheno-Pub: a total support system for the publication of mouse phenotypic data on the web.Mammalian genome : official journal of the International Mammalian Genome Society · 2013
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

C H KimberPopulation Pharmacogenetics Group, Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee, UK.
A S F Doney
E R Pearson
M I McCarthy
A T Hattersley
G P Leese
A D Morris
C N A Palmer
Ninewells Hospital · GBChurchill Hospital · GBPeninsula College of Medicine and Dentistry · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

aims/hypothesisThe gene encoding transcription factor 7-like 2 (TCF7L2) has been identified as a type 2 diabetes locus from genome-wide linkage studies and subsequent association analysis. We investigated the role of two common variants in TCF7L2 in a large case-control study recruited from the Tayside region of Scotland, UK. SUBJECTS AND

methodsWe genotyped 6,516 participants for rs12255372 and rs7903146 and analysed the role in type 2 diabetes susceptibility using binary logistic regression. Age, sex and obesity status were examined as covariates. The distribution of the genotypes within different treatment groups of cases was examined.

resultsBoth variants were associated with type 2 diabetes (p < 10(-13)). The variants were present at very similar frequencies and were in strong linkage disequilibrium (R(2) = 0.88, D' = 0.89). A gene dosage effect of the rare allele of both variants was observed, the heterozygote CT group of rs7903146 having an odds ratio of 1.36 (95% CI 1.2-1.5, p=1.54 x 10(-7)) for type 2 diabetes and the TT homozygote having a greater risk (OR = 2.03, 95% CI 1.7-2.5, p=1.40 x 10(-12)). An interaction with sex was observed, the males displaying a higher degree of genotype-associated risk compared with the females (p = 0.023). The T allele was associated with increased HbA(1c) levels in both cases and controls, and with decreased BMI and waist circumference in case but not controls. The T allele was overrepresented in individuals requiring insulin treatment and underrepresented in the patients being managed by diet alone (p = 0.006).

conclusionsWe have confirmed TCF7L2 to be a diabetes locus in a large case-control study in Tayside, UK. Our data suggest that variants of TCF7L2 may be associated with increased disease severity and therapeutic failure.

Indexed as

AgedBlood GlucoseBody Mass IndexBody SizeDiabetes MellitusDiabetes Mellitus, Type 2DNA PrimersGene DosageGenetic Predisposition to DiseaseGenetic VariationHomeostasisHumansLipidsMiddle AgedOdds RatioReference ValuesBlood GlucoseDNA PrimersLipidsTCF7L2 protein, humanTCF Transcription FactorsTranscription Factor 7-Like 2 Protein

Identifiers

PMID17429603
OpenAlexW2080878559

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.