ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Glutamatergic and purinergic receptor-mediated calcium transients in Bergmann glial cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 83 citations in OpenAlex.
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- Regulation of Neural Functions by Brain Temperature and Thermo-TRP Channels.Advances in experimental medicine and biology · 2024Review
- Altered calcium signaling in Bergmann glia contributes to spinocerebellar ataxia type-1 in a mouse model of SCA1.Neurobiology of disease · 2023Article
- Expression of expanded GGC repeats withinScience advances · 2022Article
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- Local and CNS-Wide Astrocyte Intracellular Calcium Signaling AttenuationThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Potential and Realized Impact of Astroglia CaFrontiers in cellular neuroscience · 2021Review
- Emotional Stress Induces Structural Plasticity in Bergmann Glial Cells via an AC5-CPEB3-GluA1 Pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The Role of Astrocytes in the Central Nervous System Focused on BK Channel and Heme Oxygenase Metabolites: A Review.Antioxidants (Basel, Switzerland) · 2019Review
- Neuronal Activity-Dependent Activation of Astroglial Calcineurin in Mouse Primary Hippocampal Cultures.International journal of molecular sciences · 2018Article
- TNF-α increases the intrinsic excitability of cerebellar Purkinje cells through elevating glutamate release in Bergmann Glia.Scientific reports · 2018Article
- Physiology of Astroglia.Physiological reviews · 2018Review
- Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease.Nature reviews. Neuroscience · 2017Review
- Binaural blood flow control by astrocytes: listening to synapses and the vasculature.The Journal of physiology · 2017Review
- Oxygen and Glucose Deprivation Induces Bergmann Glia Membrane Depolarization and CaFrontiers in cellular neuroscience · 2017Article
- Physiological significance of TRPV2 as a mechanosensor, thermosensor and lipid sensor.The journal of physiological sciences : JPS · 2016Review
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- Reappraisal of Bergmann glial cells as modulators of cerebellar circuit function.Frontiers in cellular neuroscience · 2015Review
- Heterogeneity in expression of functional ionotropic glutamate and GABA receptors in astrocytes across brain regions: insights from the thalamus.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
Astrocytes respond to neuronal activity with [Ca2+]i increases after activation of specific receptors. Bergmann glial cells (BGs), astrocytes of the cerebellar molecular layer (ML), express various receptors that can mobilize internal Ca2+. BGs also express Ca2+ permeable AMPA receptors that may be important for maintaining the extensive coverage of Purkinje cell (PC) excitatory synapses by BG processes. Here, we examined Ca2+ signals in single BGs evoked by synaptic activity in cerebellar slices. Short bursts of high-frequency stimulation of the ML elicited Ca2+ transients composed of a small-amplitude fast rising phase, followed by a larger and slower rising phase. The first phase resulted from Ca2+ influx through AMPA receptors, whereas the second phase required release of Ca2+ from internal stores initiated by P2 purinergic receptor activation. We found that such Ca2+ responses could be evoked by direct activation of neurons releasing ATP onto BGs or after activation of metabotropic glutamate receptor 1 on these neurons. Moreover, examination of BG and PC responses to various synaptic stimulation protocols suggested that ML interneurons are likely the cellular source of ATP.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.