ArticleJournal of clinical microbiology2007
Identification and distribution of Mycobacterium leprae genotypes in a region of high leprosy prevalence in China: a 3-year molecular epidemiological study.
Article in Journal of clinical microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Molecular epidemiological characteristics ofFrontiers in public health · 2024Article
- Genotyping ofIranian journal of microbiology · 2023Article
- Leprosy among new child cases in China: Epidemiological and clinical analysis from 2011 to 2020.PLoS neglected tropical diseases · 2023Article
- Genetic diversity of Mycobacterium leprae in the state of São Paulo, an area of low-leprosy incidence in Brazil.Revista da Sociedade Brasileira de Medicina Tropical · 2023Article
- Molecular surveillance of antimicrobial resistance and transmission pattern ofEmerging microbes & infections · 2019Article
- Multiple strain infection of Mycobacterium leprae in a family having 4 patients: A study employing short tandem repeats.PloS one · 2019Article
- Genotyping comparison of Mycobacterium leprae isolates by VNTR analysis from nasal samples in a Brazilian endemic region.Pathogens and global health · 2018Article
- Genotyping of Mycobacterium leprae for better understanding of leprosy transmission in Fortaleza, Northeastern Brazil.PLoS neglected tropical diseases · 2017Article
- Characterization of Mycobacterium leprae Genotypes in China--Identification of a New Polymorphism C251T in the 16S rRNA Gene.PloS one · 2015Article
- Molecular, ethno-spatial epidemiology of leprosy in China: novel insights for tracing leprosy in endemic and non endemic provinces.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2013Article
- Mycobacterium leprae in Colombia described by SNP7614 in gyrA, two minisatellites and geography.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2013Article
- Distribution of Mycobacterium leprae strains among cases in a rural and urban population of Maharashtra, India.Journal of clinical microbiology · 2012Article
- DNA fingerprinting of Mycobacterium leprae strains using variable number tandem repeat (VNTR) - fragment length analysis (FLA).Journal of visualized experiments : JoVE · 2011Article
- Molecular typing of Mycobacterium leprae strains from northern India using short tandem repeats.The Indian journal of medical research · 2011Article
- Transmission of leprosy in Qiubei County, Yunnan, China: insights from an 8-year molecular epidemiology investigation.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2011Article
- Mycobacterium leprae: genes, pseudogenes and genetic diversity.Future microbiology · 2011Review
- Multiplex PCR technique could be an alternative approach for early detection of leprosy among close contacts--a pilot study from India.BMC infectious diseases · 2010Article
- Comparative genomic and phylogeographic analysis of Mycobacterium leprae.Nature genetics · 2009Article
- Population-based molecular epidemiology of leprosy in Cebu, Philippines.Journal of clinical microbiology · 2009Article
- Are variable-number tandem repeats appropriate for genotyping Mycobacterium leprae?Journal of clinical microbiology · 2008Article
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8 authors.
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Abstract
Multiple-locus variable-number tandem-repeat (VNTR) analysis (MLVA) has been proposed as a means of strain typing for tracking the transmission of leprosy. However, empirical data for a defined population are lacking. To this end, a study was initiated to assess the diversity and distribution of prevalent Mycobacterium leprae strains in Qiubei County, Yunnan Province, People's Republic of China, where the annual detection rate of leprosy is 10-fold higher than the national average rate. Sixty-eight newly diagnosed leprosy patients were included in the study. MLVA at eight M. leprae loci was applied using DNA extracts from skin biopsies. The number of alleles per locus ranged from 4 to 24, providing adequate strain discrimination. MLVA strain typing identified several clusters of patients whose M. leprae specimens shared similar VNTR profiles. Two of these clusters were comprised of patients who resided predominantly in the north and northwest parts of Qiubei County. Furthermore, it was found that multicase families are common in this county: 23 of the 68 patients were from 11 families. Intrafamilial VNTR profiles closely matched within six families, although they were different between the families. Moreover, VNTR patterns related to those found in some multicase families were also detected in patients in the same or adjacent townships, indicating the utility of VNTR strain typing to identify and detect short-range transmission events. Social contact through village markets is proposed as a means of transmission.
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