Evidence map›Paper›PMID 17428873›Full record

ArticleJournal of virology2007

Diminished potential for B-lymphoid differentiation after murine leukemia virus infection in vivo and in EML hematopoietic progenitor cells.

Samantha L Finstad, Naomi Rosenberg, Laura S Levy

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Deaminase-Dead Mouse APOBEC3 Is anJournal of virology · 2018
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Samantha L FinstadDepartment of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Avenue SL-38, New Orleans, LA 70112, USA.
Naomi Rosenberg
Laura S Levy
Tulane University · USTufts University · US

Funding

SELECTIVE FORCES OPERATIVE IN FELV INFECTIONR01CA083823 · NCI · TULANE UNIVERSITY OF LOUISIANA · PI LEVY, LAURA S · 2000 to 2011
$2.8M
RNA TUMOR VIRUS/HEMATOPOIETIC CELLS INTERACTIONSR01CA033771 · NCI · TUFTS UNIVERSITY BOSTON · PI ROSENBERG, NAOMI · 1985 to 2007
$2.6M
RNA TUMOR VIRUS-HEMATOPOIETIC CELL INTERACTIONR37CA033771 · NCI · TUFTS UNIVERSITY BOSTON · PI ROSENBERG, NAOMI · 1993 to 1997
–
NCI NIH HHS CA33771NCI NIH HHS CA83823NCI NIH HHS R01 CA033771NCI NIH HHS R01 CA083823
6 · The paper itself

Abstract

Infection with a recombinant murine-feline gammaretrovirus, MoFe2, or with the parent virus, Moloney murine leukemia virus, caused significant reduction in B-lymphoid differentiation of bone marrow at 2 to 8 weeks postinfection. The suppression was selective, in that myeloid potential was significantly increased by infection. Analysis of cell surface markers and immunoglobulin H gene rearrangements in an in vitro model demonstrated normal B-lymphoid differentiation after infection but significantly reduced viability of differentiating cells. This reduction in viability may confer a selective advantage on undifferentiated lymphoid progenitors in the bone marrow of gammaretrovirus-infected animals and thereby contribute to the establishment of a premalignant state.

Indexed as

Cell DifferentiationAnimalsB-LymphocytesBone MarrowCatsHematopoiesis, ExtramedullaryLeukemia Virus, FelineMiceMoloney murine leukemia virusMyeloid Progenitor CellsRetroviridae InfectionsTumor Virus Infections

Identifiers

PMID17428873
PMCPMC1933319
OpenAlexW2153631103

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.