ArticleJournal of virology2007
The abundant R2 mRNA generated by aleutian mink disease parvovirus is tricistronic, encoding NS2, VP1, and VP2.
Article in Journal of virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Parvovirus RNA Processing: Compact Genomic Organization and Unique Alternative mRNA Processing Mechanisms.Viruses · 2025Review
- Role of the membrane-associated accessory protein (MAAP) in adeno-associated virus (AAV) infection.Journal of virology · 2024Article
- Diverse amdoparvoviruses infection of farmed Asian badgers (Meles meles).Archives of virology · 2024Article
- The 5' Untranslated Region of Human Bocavirus Capsid Transcripts Regulates Viral mRNA Biogenesis and Alternative Translation.Journal of virology · 2018Article
- The 5' Untranslated Region of the Capsid Protein 2 Gene of Mink Enteritis Virus Is Essential for Its Expression.Journal of virology · 2018Article
- Genetic characterization of the complete genome of an Aleutian mink disease virus isolated in north China.Virus genes · 2016Article
- Molecular characterization of the small nonstructural proteins of parvovirus Aleutian mink disease virus (AMDV) during infection.Virology · 2014Article
- Hybrid DNA virus in Chinese patients with seronegative hepatitis discovered by deep sequencing.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Internal polyadenylation of parvoviral precursor mRNA limits progeny virus production.Virology · 2012Article
- Molecular characterization of the newly identified human parvovirus 4 in the family Parvoviridae.Virology · 2012Article
- Role of erythropoietin receptor signaling in parvovirus B19 replication in human erythroid progenitor cells.Journal of virology · 2010Article
- The capsid proteins of Aleutian mink disease virus activate caspases and are specifically cleaved during infection.Journal of virology · 2010Article
- Adeno-associated virus type 5 utilizes alternative translation initiation to encode a small Rep40-like protein.Journal of virology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The abundant R2 mRNA encoded by the single left-end promoter of Aleutian mink disease parvovirus is tricistronic; it not only expresses the capsid proteins VP1 and VP2 but is also the major source for the nonstructural protein NS2. A cis-acting sequence within the NS2 gene was shown to be required for efficient capsid protein production, and its effect displayed a distinct location dependence. Ribosome transit through the upstream NS2 gene region was necessary for efficient VP1 and VP2 expression; however, neither ablation nor improvement of the NS2 initiating AUG had an effect on capsid protein production, suggesting that the translation of the NS2 protein per se had little influence on VP1 and VP2 expression. Thus, proper control of the alternative translation of the tricistronic R2 mRNA, a process critical for viral replication, is governed in a complex manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.