ReviewEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2007
Hormones and growth factors in the pathogenesis of spinal ligament ossification.
Review in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Global prevalence estimates of diffuse idiopathic skeletal hyperostosis: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Potential Link between Ossification of Nuchal Ligament and the Risk of Cervical Ossification of Posterior Longitudinal Ligament: Evidence and Clinical Implication from a Meta-Analysis of 8429 Participants.Orthopaedic surgery · 2021Pooled it
- Cervical Ossification of Ligamentum Flavum: Elaborating an Underappreciated but Occasional Contributor to Myeloradiculopathy in Aging Population Based on Synthesis of Individual Participant Data.Clinical interventions in aging · 2021Pooled it
- Angiogenesis in ossification of the posterior longitudinal ligament: progress from mechanism to targeted intervention.Frontiers in cell and developmental biology · 2026Review
- Axial Back Pain Secondary to Ligamentum Flavum Ossification in a Patient with Hypoparathyroidism: A Rare Case Report.Sisli Etfal Hastanesi tip bulteni · 2026Article
- The relationship between OPLL and metabolic disorders.Bone research · 2025Review
- Possible involvement of vitamin K insufficiency in the progression of cervical ossification of the posterior longitudinal ligament.Scientific reports · 2025Article
- Single-cell transcriptome profiling identifies the activation of type I interferon signaling in ossified posterior longitudinal ligament.Frontiers of medicine · 2024Article
- Correlation Between the Severity of Multifidus Fatty Degeneration and the Size of Ossification of Posterior Longitudinal Ligament at Each Spinal Level.Neurospine · 2023Article
- Lumbar Spinal Canal Stenosis in Acromegaly: A Case Report and Literature Review.Internal medicine (Tokyo, Japan) · 2023Review
- Early stages of diffuse idiopathic skeletal hyperostosis (DISH) and chronic inflammation: the Camargo Cohort Study.Clinical rheumatology · 2023Observational
- Anterior Decompression and Fusion for the Treatment of Cervical Myelopathy Caused by Ossification of the Posterior Longitudinal Ligament: A Narrative Review.Asian spine journal · 2023Article
- Thoracic Myelopathy in Ossified Ligamentum Flavum: Surgical Management and Long-Term Outcome Following 2 Different Techniques of Surgical Decompression.Global spine journal · 2023Article
- Review of Basic Research about Ossification of the Spinal Ligaments Focusing on Animal Models.Journal of clinical medicine · 2023Review
- Anatomical, morphometric and radiographic study of the humerus in lesser anteater (Tamandua mexicana Saussure, 1860): terminological and functional analyses.Anatomical science international · 2022Article
- Analysis of the surgical strategy and postoperative clinical effect of thoracic ossification of ligament flavum with dural ossification.Frontiers in surgery · 2022Article
- Diffuse Spinal Hyperostosis Causing Severe Spinal Stenosis and Thoracic Myelopathy.Orthopedic reviews · 2022Article
- Acromegaly presenting with myelopathy due to ossification of posterior longitudinal ligament: a case report.BMC musculoskeletal disorders · 2021Article
- The Natural History of Ossification of Yellow Ligament of the Thoracic Spine on MRI: A Population-Based Cohort Study.Global spine journal · 2021Article
- Degenerative Cervical Myelopathy: Insights into Its Pathobiology and Molecular Mechanisms.Journal of clinical medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ossification of the spinal ligaments (OSL) is a pathologic condition that causes ectopic bone formation and subsequently results in various degrees of neurological deficit, but the etiology of OSL remains almost unknown. Some systemic hormones, such as 1,25-dihydroxyvitamin D, parathyroid hormone (PTH), insulin and leptin, and local growth factors, such as transforming growth factor-beta (TGF-beta), and bone morphogenetic protein (BMP), have been studied and are thought to be involved in the initiation and development of OSL. This review article summarizes these studies, delineates the possible mechanisms, and puts forward doubts and new questions. The related findings from studies of genes and target cells in the ligament of OSL are also discussed. Although these findings may be helpful in understanding the pathogenesis of OSL, much more research needs to be conducted in order to investigate the nature of OSL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.