ArticleJournal of biosciences2007
Peptide segments in protein-protein interfaces.
Article in Journal of biosciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Analysis of Kinase-Peptide Interactions: DGMM Latent Constructs and Clustering Towards New Groups and Stand-Out Structures.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Benchmarking the PEPOP methods for mimicking discontinuous epitopes.BMC bioinformatics · 2019Article
- PDB-wide identification of biological assemblies from conserved quaternary structure geometry.Nature methods · 2018Article
- Protein-protein interfaces are vdW dominant with selective H-bonds and (or) electrostatics towards broad functional specificity.Bioinformation · 2017Article
- Flexibility and small pockets at protein-protein interfaces: New insights into druggability.Progress in biophysics and molecular biology · 2015Review
- A structural dissection of large protein-protein crystal packing contacts.Scientific reports · 2015Article
- 2P2Idb: a structural database dedicated to orthosteric modulation of protein-protein interactions.Nucleic acids research · 2013Article
- PRICE (PRotein Interface Conservation and Energetics): a server for the analysis of protein-protein interfaces.Journal of structural and functional genomics · 2011Article
- Deciphering the shape and deformation of secondary structures through local conformation analysis.BMC structural biology · 2011Article
- Can self-inhibitory peptides be derived from the interfaces of globular protein-protein interactions?Proteins · 2010Article
- Conserved residue clusters at protein-protein interfaces and their use in binding site identification.BMC bioinformatics · 2010Article
- Atomic analysis of protein-protein interfaces with known inhibitors: the 2P2I database.PloS one · 2010Article
- Computational analysis and determination of a highly conserved surface exposed segment in H5N1 avian flu and H1N1 swine flu neuraminidase.BMC structural biology · 2010Article
- Accessibility and partner number of protein residues, their relationship and a webserver, ContPlot for their display.BMC bioinformatics · 2009Article
- Cavities and atomic packing in protein structures and interfaces.PLoS computational biology · 2008Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An important component of functional genomics involves the understanding of protein association. The interfaces resulting from protein-protein interactions - (i) specific, as represented by the homodimeric quaternary structures and the complexes formed by two independently occurring protein components, and (ii) non-specific, as observed in the crystal lattice of monomeric proteins - have been analysed on the basis of the length and the number of peptide segments. In 1000 A2 of the interface area, contributed by a polypeptide chain, there would be 3.4 segments in homodimers, 5.6 in complexes and 6.3 in crystal contacts. Concomitantly, the segments are the longest (with 8.7 interface residues) in homodimers. Core segments (likely to contribute more towards binding) are more in number in homodimers (1.7) than in crystal contacts (0.5), and this number can be used as one of the parameters to distinguish between the two types of interfaces. Dominant segments involved in specific interactions, along with their secondary structural features, are enumerated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.