ArticleBMC health services research2007
Patient risk profiles and practice variation in nonadherence to antidepressants, antihypertensives and oral hypoglycemics.
Article in BMC health services research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Sex differences in the adherence of antihypertensive drugs: a systematic review with meta-analyses.BMJ open · 2020Pooled it
- Association between medication regimen complexity and pharmacotherapy adherence: a systematic review.European journal of clinical pharmacology · 2017Pooled it
- Multimorbidity and Patient Safety Incidents in Primary Care: A Systematic Review and Meta-Analysis.PloS one · 2015Pooled it
- Patterns of Adherence to Oral Hypoglycemic Agents and Glucose Control among Primary Care Patients with Type 2 Diabetes.Behavioral medicine (Washington, D.C.) · 2016Trial
- Medication Routines and Adherence Among Hypertensive African Americans.Journal of clinical hypertension (Greenwich, Conn.) · 2015Trial
- Improving medication adherence in diabetes type 2 patients through Real Time Medication Monitoring: a randomised controlled trial to evaluate the effect of monitoring patients' medication use combined with short message service (SMS) reminders.BMC health services research · 2011Trial
- Change in care needs of people with severe mental illness with and without a non-Western migration background: are their needs equally served throughout treatment?Social psychiatry and psychiatric epidemiology · 2025Article
- Factors Associated With Medication Compliance in Elderly Patients With Type 2 Diabetes Mellitus: A Cross-Sectional Study.Frontiers in public health · 2021Article
- Article
- Determinants of community pharmacists' quality of care: a population-based cohort study using pharmacy administrative claims data.BMJ open · 2017Article
- Dispensing of psychotropic medication among 400,000 immigrants in The Netherlands.Social psychiatry and psychiatric epidemiology · 2017Article
- The impact of age and gender on adherence to antidepressants: a 4-year population-based cohort study.Psychopharmacology · 2015Article
- Trends in the dispensation of antidepressant drugs over the past decade (2000-2010) in Andalusia, Spain.Social psychiatry and psychiatric epidemiology · 2015Article
- [Attitudes towards anti-depressive therapy: acceptance vs. stigmatization].Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2015Observational
- Patient-provider communication, self-reported medication adherence, and race in a postmyocardial infarction population.Patient preference and adherence · 2015Article
- The development of the ProMAS: a Probabilistic Medication Adherence Scale.Patient preference and adherence · 2015Article
- Antidepressant utilization after hospitalization with depression: a comparison between non-Western immigrants and Danish-born residents.BMC psychiatry · 2014Article
- Relationship between medication beliefs, self-reported and refill adherence, and symptoms in patients with asthma using inhaled corticosteroids.Patient preference and adherence · 2014Article
- Lazy sunday afternoons: the negative impact of interruptions in patients' daily routine on adherence to oral antidiabetic medication. A multilevel analysis of electronic monitoring data.European journal of clinical pharmacology · 2013Article
- Measuring concurrent oral hypoglycemic and antidepressant adherence and clinical outcomes.The American journal of managed care · 2013Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany patients experience difficulties in following treatment recommendations. This study's objective is to identify nonadherence risk profiles regarding medication (antidepressants, antihypertensives, and oral hypoglycemics) from a combination of patients' socio-demographic characteristics, morbidity presented within general practice and medication characteristics. An additional objective is to explore differences in nonadherence among patients from different general practices.
methodsData were obtained by linkage of a Dutch general practice registration database to a dispensing registration database from the year 2001. Subjects included in the analyses were users of antidepressants (n = 4,877), antihypertensives (n = 14,219), or oral hypoglycemics (n = 2,428) and their GPs. Outcome variables were: 1) early dropout i.e., a maximum of two prescriptions and 2) refill nonadherence (in patients with 3+ prescriptions); refill adherence < 80% was considered as nonadherence. Multilevel modeling was used for analyses.
resultsBoth early dropout and refill nonadherence were highest for antidepressants, followed by antihypertensives. Risk factors appeared medication specific and included: 1) non-western immigrants being more vulnerable for nonadherence to antihypertensives and antidepressants; 2) type of medication influencing nonadherence in both antihypertensives and antidepressants, 3) GP consultations contributing positively to adherence to antihypertensives and 4) somatic co-morbidity influencing adherence to antidepressants negatively. There was a considerable range between general practices in the proportion of patients who were nonadherent.
conclusionNo clear risk profiles for nonadherence could be constructed. Characteristics that are correlated with nonadherence vary across different types of medication. Moreover, both patient and prescriber influence adherence. Especially non-western immigrants need more attention with regard to nonadherence, for example by better monitoring or communication. Since it is not clear which prescriber characteristics influence adherence levels of their patients, there is need for further research into the role of the prescriber.
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