ArticleCancer science2007
Hypoxia increases the motility of lung adenocarcinoma cell line A549 via activation of the epidermal growth factor receptor pathway.
Article in Cancer science, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Expression patterns of HNF4α, TTF-1, and SMARCA4 in lung adenocarcinomas: impacts on clinicopathological and genetic features.Virchows Archiv : an international journal of pathology · 2025Article
- Differential effects of hypoxia on motility using various in vitro models of lung adenocarcinoma.Scientific reports · 2024Article
- Review of cancer cell volatile organic compounds: their metabolism and evolution.Frontiers in molecular biosciences · 2024Review
- Genetic and phenotypic determinants of morphologies in 3D cultures and xenografts of lung tumor cell lines.Cancer science · 2023Article
- Review
- Reciprocal expression of trefoil factor-1 and thyroid transcription factor-1 in lung adenocarcinomas.Cancer science · 2020Article
- Design, synthesis, and biological study of 4-[(2-nitroimidazole-1Drug design, development and therapy · 2019Article
- Tumor-Associated CD204-Positive Macrophage Is a Prognostic Marker in Clinical Stage I Lung Adenocarcinoma.BioMed research international · 2018Article
- Hypoxia-induced proliferation of HeLa cells depends on epidermal growth factor receptor-mediated arginase II induction.Physiological reports · 2017Article
- Design and Synthesis of Vandetanib Derivatives Containing Nitroimidazole Groups as Tyrosine Kinase Inhibitors in Normoxia and Hypoxia.Molecules (Basel, Switzerland) · 2016Article
- A simple non-perturbing cell migration assay insensitive to proliferation effects.Scientific reports · 2016Article
- Shared Genetic Signals of Hypoxia Adaptation in Drosophila and in High-Altitude Human Populations.Molecular biology and evolution · 2016Article
- Hypoxia suppression of Bim and Bmf blocks anoikis and luminal clearing during mammary morphogenesis.Molecular biology of the cell · 2010Article
- Co-activation of epidermal growth factor receptor and c-MET defines a distinct subset of lung adenocarcinomas.The American journal of pathology · 2010Article
- Pgrmc1 (progesterone receptor membrane component 1) associates with epidermal growth factor receptor and regulates erlotinib sensitivity.The Journal of biological chemistry · 2010Article
- Growth factors in tumor microenvironment.Frontiers in bioscience (Landmark edition) · 2010Review
- Role of cGMP-dependent protein kinase in regulation of pulmonary vascular smooth muscle cell adhesion and migration: effect of hypoxia.American journal of physiology. Heart and circulatory physiology · 2009Article
- Constitutive activation of c-Met is correlated with c-Met overexpression and dependent on cell-matrix adhesion in lung adenocarcinoma cell lines.Cancer science · 2008Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor hypoxia is associated with a malignant phenotype of cancer cells and poor patient prognosis. To investigate the role of hypoxia in tumor progression, we studied the effects of hypoxia in the A549 lung adenocarcinoma cell line. First, we showed that hypoxic treatment decreased cell-cell adhesion and induced a scattering of cancer cells. Concomitant with these morphological changes, the motility of cancer cells was increased, as demonstrated by the Boyden chamber assay. Then, we used oligonucleotide array analyses to identify the genes causally related to the hypoxia-induced motile phenotype. The results showed that the expression of approximately 100 genes was induced more than 5-fold by hypoxia. These included (among others) epidermal growth factor receptor (EGFR), as well as other well-known hypoxia-induced genes, such as vascular endothelial growth factor. Immunohistochemical analyses of primary lung adenocarcinomas confirmed the induction of EGFR in tumor cells in the vicinity of necrotic areas, a histological indicator of tumor hypoxia. Remarkably, the EGFR inhibitor AG1478 (10 microM) completely blocked the increased cell motility induced by hypoxia. Thus, the present study demonstrates the importance of the EGFR pathway in the increased motility of cancer cells that occurs in a hypoxic tumor environment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.