IL2RA/CD25 polymorphisms contribute to multiple sclerosis susceptibility.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

23 citing papers in PubMed.

1. Regulatory T cells in rheumatoid arthritis: functions, development, regulation, and therapeutic potential.Cellular and molecular life sciences : CMLS · 2022
   Review
2. The IL-2 - IL-2 receptor pathway: Key to understanding multiple sclerosis.Journal of translational autoimmunity · 2021
   Review
3. Association ofReports of biochemistry & molecular biology · 2020
   Article
4. Where is the causal variant? On the advantage of the family design over the case-control design in genetic association studies.European journal of human genetics : EJHG · 2015
   Article
5. Plasma concentrations of soluble IL-2 receptor α (CD25) are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients.Diabetologia · 2014
   Article
6. Multiple autoimmune-associated variants confer decreased IL-2R signaling in CD4+ CD25(hi) T cells of type 1 diabetic and multiple sclerosis patients.PloS one · 2013
   Article
7. Determination of the real effect of genes identified in GWAS: the example of IL2RA in multiple sclerosis.European journal of human genetics : EJHG · 2012
   Article
8. Sample reproducibility of genetic association using different multimarker TDTs in genome-wide association studies: characterization and a new approach.PloS one · 2012
   Article
9. Genetics of experimental allergic encephalomyelitis supports the role of T helper cells in multiple sclerosis pathogenesis.Annals of neurology · 2011
   Article
10. Immunogenetic mechanisms leading to thyroid autoimmunity: recent advances in identifying susceptibility genes and regions.Current genomics · 2011
    Article
11. An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(+) T cells.Genes and immunity · 2011
    Article
12. Polymorphisms in the IL2, IL2RA and IL2RB genes in multiple sclerosis risk.European journal of human genetics : EJHG · 2010
    Article
13. Tag-SNP analysis of the GFI1-EVI5-RPL5-FAM69 risk locus for multiple sclerosis.European journal of human genetics : EJHG · 2010
    Article
14. Hexose-6-phosphate dehydrogenase: a new risk gene for multiple sclerosis.European journal of human genetics : EJHG · 2010
    Article
15. HLA class II alleles in patients with multiple sclerosis in the Biscay province (Basque Country, Spain).Journal of neurology · 2009
    Article
16. Low frequency of CD4+CD25+ Treg in SLE patients: a heritable trait associated with CTLA4 and TGFbeta gene variants.BMC immunology · 2009
    Article
17. IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production.PLoS genetics · 2009
    Article
18. IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D).PloS one · 2009
    Article
19. Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians.Genes and immunity · 2008
    Article
20. Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations.Journal of medical genetics · 2008
    Article

Corrections and comments

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Authors and funding

8 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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