ReviewCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2007
Hypertriglyceridemia: its etiology, effects and treatment.
Review in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 189 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
189 citing papers in PubMed, 616 citations in OpenAlex.
- Association Between Triglycerides and Risk of Dementia in Community-Dwelling Older Adults: A Prospective Cohort Study.Neurology · 2023Trial
- The FGF21 analog pegozafermin in severe hypertriglyceridemia: a randomized phase 2 trial.Nature medicine · 2023Trial
- Association of Non-LDL Indices with Recurrent Stroke Risk while on Lipid-Modifying Therapy.Journal of atherosclerosis and thrombosis · 2020Trial
- Acute and residual effects of aerobic exercise on fructose-induced postprandial lipemia on lean male subjects.European journal of nutrition · 2019Trial
- Mediterranean-style diet in pregnant women with metabolic risk factors (ESTEEM): A pragmatic multicentre randomised trial.PLoS medicine · 2019Trial
- The effect of bezafibrate and omega-3 fatty acids on lymphocyte cytokine release and systemic inflammation in patients with isolated hypertriglyceridemia.European journal of clinical pharmacology · 2011Trial
- Trial
- Lupin protein compared to casein lowers the LDL cholesterol:HDL cholesterol-ratio of hypercholesterolemic adults.European journal of nutrition · 2010Trial
- Consumption of medium- and long-chain triacylglycerols decreases body fat and blood triglyceride in Chinese hypertriglyceridemic subjects.European journal of clinical nutrition · 2009Trial
- Lipoprotein lipase deficiency presenting with gastrointestinal bleeding and compensated shock.JCEM case reports · 2026Article
- Propofol-induced hypertriglyceridemia in critically ill trauma patients requiring nutrition therapy: A descriptive cohort study.JPEN. Journal of parenteral and enteral nutrition · 2026Article
- Familial Hyperchylomicronemia Syndrome in a Term Neonate.Annals of African medicine · 2026Article
- Hypertriglyceridaemia-Associated Acute Pancreatitis: Pathophysiological Insights and Advances in Clinical Management.Biomedicines · 2026Review
- From Phenotype to Genotype and Beyond: Insights into Familial Hypercholesterolemia and Familial Hypertriglyceridemia.Medicina (Kaunas, Lithuania) · 2026Review
- Asymmetric dimethylguanidino valeric acid as an independently associated risk factor for early hypertriglyceridemia and dyslipidemia.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Protective Effect ofFood science & nutrition · 2026Article
- Development of a machine learning model for predicting pre-sarcopenia in adults with abdominal obesity: a cross-sectional study.Journal of endocrinological investigation · 2026Article
- Relationship between serum iron and the severity of hypertriglyceridemic acute pancreatitis.Revista da Associacao Medica Brasileira (1992) · 2026Article
- Navigating hypertriglyceridemia in pregnancy: current evidence and clinical strategies.Frontiers in endocrinology · 2026Review
- Case Report: Conventional therapy versus volanesorsen in two sisters with familial chylomicronemia syndrome.Frontiers in nutrition · 2026Article
129 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elevated plasma triglyceride concentration is a common biochemical finding, but the evidence for the benefit of treating this lipid disturbance remains less robust than that for treating elevated low-density lipoprotein-cholesterol. Part of the difficulty in the provision of specific recommendations has been the frequent coexistence of elevated triglycerides with other conditions that affect cardiovascular disease risk, such as depressed high-density lipoprotein-cholesterol, obesity, metabolic syndrome, proinflammatory and prothrombotic biomarkers, and type 2 diabetes. Recent investigations of outcomes of cardiovascular disease when medications are used to reduce triglyceride levels suggest that, although a net benefit probably exists, both relative and absolute risk reductions seem underwhelming when compared with the benefit of reducing low-density lipoprotein-cholesterol levels with treatment. However, the totality of evidence suggests that elevated triglyceride levels likely contribute independently to increased risk of cardiovascular disease, although there is no consensus about appropriate target levels. Furthermore, severe hypertriglyceridemia is associated with an increased risk of acute pancreatitis, irrespective of its effect on risk of cardiovascular disease. We review the causes and classification of elevated triglyceride levels, the clinical manifestations of primary hypertriglyceridemia and the management of patients with elevated triglyceride levels.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.