ArticleProceedings of the National Academy of Sciences of the United States of America2007
A cortical potential reflecting cardiac function.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.
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Who cites it
76 citing papers in PubMed, 1 synthesis or guideline pooled it, 228 citations in OpenAlex.
- Heartbeat-Evoked Responses in M/EEG: A Systematic Review of Methods With Suggestions for Analysis and Reporting.Psychophysiology · 2026Pooled it
- Trial
- Use of an allostatic neurotechnology by adolescents with postural orthostatic tachycardia syndrome (POTS) is associated with improvements in heart rate variability and changes in temporal lobe electrical activity.Experimental brain research · 2016Trial
- The Human Intracerebral EEG Platform: A Cloud-Based Trusted Research Environment for Collaborative SEEG Research in Epilepsy and Neuroscience.European journal of neurology · 2026Review
- Heartbeat-evoked potentials reveal interoceptive dysfunction in clinical disorders: Experimental frameworks and promising applications.Psychological medicine · 2026Review
- Two-hour nicotine withdrawal does not alter interoceptive dysfunction in male smokers with nicotine dependence: evidence from heartbeat-evoked potentials.BMC psychiatry · 2026Article
- Review of methods to derive the heartbeat-evoked potential: past practices and future directions.Social cognitive and affective neuroscience · 2026Review
- Cardiac interoception in chronic pain: no association between interoceptive accuracy and symptom report.Frontiers in psychiatry · 2026Article
- Interoceptive profiles of eating and weight disorders.Scientific reports · 2025Article
- Comparison of three behavioral cardioception tasks and heartbeat evoked potentials in the same group of healthy volunteers.Scientific reports · 2025Article
- Neural and Cardiac Contributions to Perceptual Suppression During Cycling.Psychophysiology · 2025Article
- Neurophysiological dynamics of visceral signals in emotion, self and bodily consciousness.Proceedings. Biological sciences · 2025Review
- Validating genuine changes in heartbeat-evoked potentials using pseudotrials and surrogate procedures.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Exploring the Link Between Interoception and Symptom Severity in Premature Ventricular Contractions.Journal of clinical medicine · 2024Article
- Individual Differences in Bodily Self-Consciousness and Its Neural Basis.Brain sciences · 2024Review
- Heart-Brain Axis: A Narrative Review of the Interaction between Depression and Arrhythmia.Biomedicines · 2024Review
- Attention to cardiac sensations enhances the heartbeat-evoked potential during exhalation.iScience · 2024Article
- Single neurons in the thalamus and subthalamic nucleus process cardiac and respiratory signals in humans.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Heartbeat-evoked potentials following voluntary hyperventilation in epilepsy patients: respiratory influences on cardiac interoception.Frontiers in neuroscience · 2024Article
- Psychological stress, the central nervous system and arrhythmias.QJM : monthly journal of the Association of Physicians · 2023Review
16 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
Emotional trauma and psychological stress can precipitate cardiac arrhythmia and sudden death through arrhythmogenic effects of efferent sympathetic drive. Patients with preexisting heart disease are particularly at risk. Moreover, generation of proarrhythmic activity patterns within cerebral autonomic centers may be amplified by afferent feedback from a dysfunctional myocardium. An electrocortical potential reflecting afferent cardiac information has been described, reflecting individual differences in interoceptive sensitivity (awareness of one's own heartbeats). To inform our understanding of mechanisms underlying arrhythmogenesis, we extended this approach, identifying electrocortical potentials corresponding to the cortical expression of afferent information about the integrity of myocardial function during stress. We measured changes in cardiac response simultaneously with electroencephalography in patients with established ventricular dysfunction. Experimentally induced mental stress enhanced cardiovascular indices of sympathetic activity (systolic blood pressure, heart rate, ventricular ejection fraction, and skin conductance) across all patients. However, the functional response of the myocardium varied; some patients increased, whereas others decreased, cardiac output during stress. Across patients, heartbeat-evoked potential amplitude at left temporal and lateral frontal electrode locations correlated with stress-induced changes in cardiac output, consistent with an afferent cortical representation of myocardial function during stress. Moreover, the amplitude of the heartbeat-evoked potential in the left temporal region reflected the proarrhythmic status of the heart (inhomogeneity of left ventricular repolarization). These observations delineate a cortical representation of cardiac function predictive of proarrhythmic abnormalities in cardiac repolarization. Our findings highlight the dynamic interaction of heart and brain in stress-induced cardiovascular morbidity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.