ArticleMolecular and cellular biology2007
Characterization of mammalian Par 6 as a dual-location protein.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Par6/SOX2 interact to modulate stemness maintenance in glioma by regulating the EGFR/PI3K/AKT signaling cascade.Oncogene · 2025Article
- Re-assessment of the subcellular localization of Bazooka/Par-3 in Drosophila: no evidence for localization to the nucleus and the neuromuscular junction.Biology open · 2024Article
- Article
- Establishment of Par-Polarized Cortical Domains via Phosphoregulated Membrane Motifs.Developmental cell · 2015Article
- Par6b regulates the dynamics of apicobasal polarity during development of the stratified Xenopus epidermis.PloS one · 2013Article
- Functional comparison of protein domains within aPKCs involved in nucleocytoplasmic shuttling.Biology open · 2012Article
- Epithelial cell polarity and tumorigenesis: new perspectives for cancer detection and treatment.Acta pharmacologica Sinica · 2011Review
- Par6 alpha interacts with the dynactin subunit p150 Glued and is a critical regulator of centrosomal protein recruitment.Molecular biology of the cell · 2010Article
- Tissue polarity-dependent control of mammary epithelial homeostasis and cancer development: an epigenetic perspective.Journal of mammary gland biology and neoplasia · 2010Review
- Son is essential for nuclear speckle organization and cell cycle progression.Molecular biology of the cell · 2010Article
- Junctional music that the nucleus hears: cell-cell contact signaling and the modulation of gene activity.Cold Spring Harbor perspectives in biology · 2009Review
- Polarity proteins and cell-cell interactions in the testis.International review of cell and molecular biology · 2009Review
- The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer.Cancer research · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Par 6 acts as a scaffold protein to facilitate atypical protein kinase C-mediated phosphorylation of cytoplasmic protein complexes, leading to epithelial and neuronal cell polarization. In addition to its location in the cytoplasm, Par 6 is localized to the nucleus. However, its organization and potential functions in the nucleus have not been examined. Using an affinity-purified Par 6 antibody and a chimera of Par 6 and green fluorescent protein, we show that Par 6 localizes precisely to nuclear speckles, but not to other nuclear structures, and displays characteristics of speckle proteins. We show that Par 6 colocalizes in the nucleus with Tax, a transcriptional activator of the human T-cell leukemia virus type 1 long terminal repeat, but multiple lines of evidence show that Par 6 is not directly involved in known functions of speckle proteins, including general transcription, splicing, or mRNA transport. Significantly, however, the structure of nuclear speckles is lost when Par 6 levels are reduced by Par 6-specific small interfering RNA. Therefore, we hypothesize that Par 6 in the nucleus acts as a scaffolding protein in nuclear speckle complexes, similar to its role in the cytoplasm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.