ArticleMolecular and cellular biology2007
DNA structure-induced recruitment and activation of the Fanconi anemia pathway protein FANCD2.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Critical role of alpha spectrin in DNA repair: the importance of μ-calpain and Fanconi anemia proteins.Experimental biology and medicine (Maywood, N.J.) · 2025Review
- The functional importance of lamins, actin, myosin, spectrin and the LINC complex in DNA repair.Experimental biology and medicine (Maywood, N.J.) · 2019Review
- The Fanconi Anemia Pathway in Cancer.Annual review of cancer biology · 2019Article
- Article
- The identification of FANCD2 DNA binding domains reveals nuclear localization sequences.Nucleic acids research · 2017Article
- Chromosomal Integrity after UV Irradiation Requires FANCD2-Mediated Repair of Double Strand Breaks.PLoS genetics · 2016Article
- FANCD2 is a potential therapeutic target and biomarker in alveolar rhabdomyosarcoma harboring the PAX3-FOXO1 fusion gene.Clinical cancer research : an official journal of the American Association for Cancer Research · 2014Article
- The genetic and biochemical basis of FANCD2 monoubiquitination.Molecular cell · 2014Article
- Regulation of FANCD2 and FANCI monoubiquitination by their interaction and by DNA.Nucleic acids research · 2014Article
- The Fanconi anemia ID2 complex: dueling saxes at the crossroads.Cell cycle (Georgetown, Tex.) · 2014Review
- FANCD2 regulates BLM complex functions independently of FANCI to promote replication fork recovery.Nucleic acids research · 2013Article
- Fanconi anemia proteins FANCD2 and FANCI exhibit different DNA damage responses during S-phase.Nucleic acids research · 2012Article
- DNA robustly stimulates FANCD2 monoubiquitylation in the complex with FANCI.Nucleic acids research · 2012Article
- The FANC pathway is activated by adenovirus infection and promotes viral replication-dependent recombination.Nucleic acids research · 2011Article
- Monoketone analogs of curcumin, a new class of Fanconi anemia pathway inhibitors.Molecular cancer · 2009Article
- The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways.The Journal of biological chemistry · 2009Article
- Checkpoint signaling from a single DNA interstrand crosslink.Molecular cell · 2009Article
- MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair.The EMBO journal · 2009Article
- Fanconi anemia: a paradigm of discovering molecular pathways from patients.Mutation research · 2009Article
- Fanconi anemia proteins stabilize replication forks.DNA repair · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The Fanconi anemia (FA) pathway proteins are thought to be involved in the repair of irregular DNA structures including those encountered by the moving replication fork. However, the nature of the DNA structures that recruit and activate the FA proteins is not known. Because FA proteins function within an extended network of proteins, some of which are still unknown, we recently established cell-free assays in Xenopus laevis egg extracts to deconstruct the FA pathway in a fully replication-competent context. Here we show that the central FA pathway protein, xFANCD2, is monoubiquitinated (xFANCD2-L) rapidly in the presence of linear and branched double-stranded DNA (dsDNA) structures but not single-stranded or Y-shaped DNA. xFANCD2-L associates with dsDNA structures in an FA core complex-dependent manner but independently of xATRIP, the regulatory subunit of xATR. Formation of xFANCD2-L is also triggered in response to circular dsDNA, suggesting that dsDNA ends are not required to trigger monoubiquitination of FANCD2. The induction of xFANCD2-L in response to circular dsDNA is replication and checkpoint independent. Our results provide new evidence that the FA pathway discriminates among DNA structures and demonstrate that triggering the FA pathway can be uncoupled from DNA replication and ATRIP-dependent activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.