ArticleInfection and immunity2007
Identification of midgut and salivary glands as specific and distinct barriers to efficient tick-borne transmission of Anaplasma marginale.
Article in Infection and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
51 citing papers in PubMed, 90 citations in OpenAlex.
- Adaptation ofmSphere · 2026Article
- Nomenclature, classification, and in-silico structural analysis of MSP1a variants of Anaplasma marginale.PloS one · 2026Article
- Alterations in the salivary gland microbiota ofZoological research · 2025Article
- In Situ Localization ofPathogens (Basel, Switzerland) · 2024Article
- Identification ofInfection and immunity · 2024Article
- Tissue-specific localization of tick-borne pathogens in ticks collected from camels in Kenya: insights into vector competence.Frontiers in cellular and infection microbiology · 2024Article
- Epidemiology ofInternational journal for parasitology. Parasites and wildlife · 2023Article
- Molecular detection and characterization ofFrontiers in veterinary science · 2023Article
- Identification of microRNAs in the Lyme Disease VectorInternational journal of molecular sciences · 2022Article
- Interactions ofInternational journal of molecular sciences · 2022Review
- Iron Reduction inInternational journal of molecular sciences · 2022Article
- Interactions Between Ticks and Lyme Disease Spirochetes.Current issues in molecular biology · 2021Article
- Identification of Tick-Borne Pathogens and Genotyping ofFrontiers in microbiology · 2021Article
- A Technique for Dissecting the Salivary Glands From the Abdomens of Deer Keds (Diptera: Hippoboscidae: Lipoptena Nitzsch, 1818 and Neolipoptena Bequaert, 1942).Journal of insect science (Online) · 2020Article
- Interrupted Blood Feeding in Ticks: Causes and Consequences.Microorganisms · 2020Review
- Microbiome analysis of the saliva and midgut from partially or fully engorged female adult Dermacentor silvarum ticks in China.Experimental & applied acarology · 2020Article
- Quantitative analysis of Anaplasma marginale acquisition and transmission by Dermacentor andersoni fed in vitro.Scientific reports · 2020Article
- Seroprevalence and Molecular Detection of Bovine Anaplasmosis in Egypt.Pathogens (Basel, Switzerland) · 2020Article
- Assessment of bacterial diversity of Rhipicephalus microplus ticks from two livestock agroecosystems in Antioquia, Colombia.PloS one · 2020Article
- Tick-borne pathogen detection in midgut and salivary glands of adult Ixodes ricinus.Parasites & vectors · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Understanding the determinants of efficient tick-borne microbial transmission is needed to better predict the emergence of highly transmissible pathogen strains and disease outbreaks. Although the basic developmental cycle of Anaplasma and Ehrlichia spp. within the tick has been delineated, there are marked differences in the ability of specific strains to be efficiently tick transmitted. Using the highly transmissible St. Maries strain of Anaplasma marginale in Dermacentor andersoni as a positive control and two unrelated nontransmissible strains, we identified distinct barriers to efficient transmission within the tick. The Mississippi strain was unable to establish infection at the level of the midgut epithelium despite successful ingestion of infected blood following acquisition feeding on a bacteremic animal host. This inability to colonize the midgut epithelium prevented subsequent development within the salivary glands and transmission. In contrast, A. marginale subsp. centrale colonized the midgut and then the salivary glands, replicating to a titer indistinguishable from that of the highly transmissible St. Maries strain and at least 100 times greater than that previously associated with successful transmission. Nonetheless, A. marginale subsp. centrale was not transmitted, even when a large number of infected ticks was used for transmission feeding. These results establish that there are at least two specific barriers to efficient tick-borne transmission, the midgut and salivary glands, and highlight the complexity of the pathogen-tick interaction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.