ArticleAntimicrobial agents and chemotherapy2007
Comprehensive analysis of the effects of ordinary nutrients on hepatitis C virus RNA replication in cell culture.
Article in Antimicrobial agents and chemotherapy, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01274013 (A Pilot Study on Vitamin D Deficiency in Subjects With Chronic Hepatitis C Compared to Healthy Volunteers), which is not on this map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Study on Vitamin D Deficiency in Subjects With Chronic Hepatitis C Compared to Healthy Volunteers
Who cites it
33 citing papers in PubMed, 85 citations in OpenAlex.
- Vitamin D Status and Virologic Response to HCV Therapy in the HALT-C and VIRAHEP-C Trials.PloS one · 2016Trial
- Identification of (20R)-protopanaxadiol from Panax ginseng as a novel anti-SARS-CoV-2 compound.FEBS open bio · 2026Article
- Retinoids in the Pathogenesis and Treatment of Liver Diseases.Nutrients · 2022Review
- Article
- Iron Chelation in Local Infection.Molecules (Basel, Switzerland) · 2021Review
- Regulation of Hepatitis C Virus Infection by Cellular Retinoic Acid Binding Proteins through the Modulation of Lipid Droplet Abundance.Journal of virology · 2019Article
- Review
- Vitamin D and the Liver-Correlation or Cause?Nutrients · 2018Review
- Relationship between Hepatitis C Virus Infection and Iron Overload.Chinese medical journal · 2017Review
- Gallic acid decreases hepatitis C virus expression through its antioxidant capacity.Experimental and therapeutic medicine · 2016Article
- Isolation and characterization of hepatitis C virus resistant to a novel phenanthridinone derivative.Antiviral chemistry & chemotherapy · 2015Article
- Hepcidin/ferroportin expression levels involve efficacy of pegylated-interferon plus ribavirin in hepatitis C virus-infected liver.World journal of gastroenterology · 2015Article
- Vitamin D deficiency in chronic liver disease.World journal of hepatology · 2014Review
- Vitamin D Metabolites Inhibit Hepatitis C Virus and Modulate Cellular Gene Expression.Journal of virology & antiviral research · 2014Article
- Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation.Nature medicine · 2014Article
- The acyclic retinoid Peretinoin inhibits hepatitis C virus replication and infectious virus release in vitro.Scientific reports · 2014Article
- Hepatitis C virus-induced mitochondrial dysfunctions.Viruses · 2013Review
- Interplay between Hepatitis C Virus and Redox Cell Signaling.International journal of molecular sciences · 2013Article
- New preclinical antimalarial drugs potently inhibit hepatitis C virus genotype 1b RNA replication.PloS one · 2013Article
- Theoretical basis of a beneficial role for vitamin D in viral hepatitis.World journal of gastroenterology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To date, only a limited number of studies have reported finding an influence of ordinary nutrients on hepatitis C virus (HCV) RNA replication. However, the effects of other nutrients on HCV RNA replication remain largely unknown. We recently developed a reporter assay system for genome-length HCV RNA replication in hepatoma-derived HuH-7 cells (OR6). Here, using this OR6 assay system, we comprehensively examined 46 nutrients from four nutrient groups: vitamins, amino acids, fatty acids, and salts. We found that three nutrients-beta-carotene, vitamin D(2), and linoleic acid-inhibited HCV RNA replication and that their combination caused additive and/or synergistic effects on HCV RNA replication. In addition, combined treatment with each of the three nutrients and interferon alpha or beta or fluvastatin inhibited HCV RNA replication in an additive manner, while combined treatment with cyclosporine synergistically inhibited HCV RNA replication. In contrast, we found that vitamin E enhanced HCV RNA replication and negated the effects of the three anti-HCV nutrients and cyclosporine but not those of interferon or fluvastatin. These results will provide useful information for the treatment of chronic hepatitis C patients who also take anti-HCV nutrients as an adjunctive therapy in combination with interferon. In conclusion, among the ordinary nutrients tested, beta-carotene, vitamin D(2), and linoleic acid possessed anti-HCV activity in a cell culture system, and these nutrients are therefore considered to be potential candidates for enhancing the effects of interferon therapy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.