ArticleExperimental parasitology2007
Nippostrongylus brasiliensis: identification of intelectin-1 and -2 as Stat6-dependent genes expressed in lung and intestine during infection.
Article in Experimental parasitology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- Intelectin-2 is a broad-spectrum antimicrobial lectin.Nature communications · 2026Article
- Exploring the Role of Lactoferrin in Managing Allergic Airway Diseases among Children: Unrevealing a Potential Breakthrough.Nutrients · 2024Review
- Gut microbiota alternation under the intestinal epithelium-specific knockout of mouse Piga gene.Scientific reports · 2022Article
- NAD(P)H fluorescence lifetime imaging of live intestinal nematodes reveals metabolic crosstalk between parasite and host.Scientific reports · 2022Article
- Characterization of an intelectin-1 (Frontiers in immunology · 2022Article
- Small proline-rich protein 2A is a gut bactericidal protein deployed during helminth infection.Science (New York, N.Y.) · 2021Article
- Extensive variation in the intelectin gene family in laboratory and wild mouse strains.Scientific reports · 2021Article
- Human intelectin-1 (ITLN1) genetic variation and intestinal expression.Scientific reports · 2021Article
- Bovine Intelectin 2 Expression as a Biomarker of Paratuberculosis Disease Progression.Animals : an open access journal from MDPI · 2021Article
- Genome-wide insights on gastrointestinal nematode resistance in autochthonous Tunisian sheep.Scientific reports · 2021Article
- Review
- Stereoelectronic Effects Impact Glycan Recognition.Journal of the American Chemical Society · 2020Article
- Functional characterization of a subtilisin-like serine protease fromThe Journal of biological chemistry · 2019Article
- Intelectin 3 is dispensable for resistance against a mycobacterial infection in zebrafish (Danio rerio).Scientific reports · 2019Article
- Intelectin contributes to allergen-induced IL-25, IL-33, and TSLP expression and type 2 response in asthma and atopic dermatitis.Mucosal immunology · 2017Article
- Defensins, lectins, mucins, and secretory immunoglobulin A: microbe-binding biomolecules that contribute to mucosal immunity in the human gut.Critical reviews in biochemistry and molecular biology · 2017Review
- Chemoproteomic profiling of host and pathogen enzymes active in cholera.Nature chemical biology · 2016Article
- The impact of acute aerobic exercise on chitinase 3-like protein 1 and intelectin-1 expression in obesity.Experimental biology and medicine (Maywood, N.J.) · 2016Article
- Autophagy Protects against Colitis by the Maintenance of Normal Gut Microflora and Secretion of Mucus.The Journal of biological chemistry · 2015Article
- Recognition of microbial glycans by human intelectin-1.Nature structural & molecular biology · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Elimination of the helminth parasite Nippostrongylus brasiliensis from infected mice is mediated by IL-4 or IL-13 and dependent on the IL-4Ralpha chain and the transcription factor Stat6 in non-hematopoietic cells. However, it is not clear which Stat6-dependent effector molecules mediate worm expulsion. We identified intelectin-1 and -2 as Stat6-dependent genes that are induced during infection. Intelectins can bind galactofuranose, a sugar present only in microorganisms and might therefore serve as microbial pattern element. To analyze whether constitutive expression of intelectin-1 or -2 leads to accelerated pathogen clearance, transgenic mice were generated which express high levels of these genes selectively in the lung. Infection with N. brasiliensis or Mycobacterium tuberculosis did not result in accelerated pathogen clearance in transgenic as compared to wild-type mice. Further, no significant modulation of the immune response in lung or lymph nodes was observed. Thus, under these conditions, intelectins did not enhance pathogen clearance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.