ArticleDevelopmental cell2007
Centrosomes promote timely mitotic entry in C. elegans embryos.
Article in Developmental cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
53 citing papers in PubMed, 91 citations in OpenAlex.
- Big1 is a cell-cycle regulator linking cell size to basal body number in Tetrahymena thermophila.Current biology : CB · 2026Article
- Big1 is a cell cycle regulator linking cell size to basal body number.bioRxiv : the preprint server for biology · 2025Article
- Article
- CDK activity at the centrosome regulates the cell cycle.Cell reports · 2024Article
- Extra centrosomes induce PIDD1-mediated inflammation and immunosurveillance.The EMBO journal · 2023Article
- Centriolar subdistal appendages promote double-strand break repair through homologous recombination.EMBO reports · 2023Article
- A membrane reticulum, the centriculum, affects centrosome size and function in Caenorhabditis elegans.Current biology : CB · 2023Article
- Aurora A and cortical flows promote polarization and cytokinesis by inducing asymmetric ECT-2 accumulation.eLife · 2022Article
- Micronuclei from misaligned chromosomes that satisfy the spindle assembly checkpoint in cancer cells.Current biology : CB · 2022Article
- An updated view on the centrosome as a cell cycle regulator.Cell division · 2022Review
- Keep Calm and Carry on with Extra Centrosomes.Cancers · 2022Review
- The LEM-ESCRT toolkit: Repair and maintenance of the nucleus.Frontiers in cell and developmental biology · 2022Review
- Redistribution of centrosomal proteins by centromeres and Polo kinase controls partial nuclear envelope breakdown in fission yeast.Molecular biology of the cell · 2021Article
- Centriolar distal appendages activate the centrosome-PIDDosome-p53 signalling axis via ANKRD26.The EMBO journal · 2021Article
- Centrosome Aurora A gradient ensures single polarity axis in C. elegans embryos.Biochemical Society transactions · 2020Review
- Centrosome Aurora A regulates RhoGEF ECT-2 localisation and ensures a single PAR-2 polarity axis inDevelopment (Cambridge, England) · 2019Article
- Protein phase separation in mitosis.Current opinion in cell biology · 2019Review
- Cyclin CYB-3 controls both S-phase and mitosis and is asymmetrically distributed in the early C. elegans embryo.Development (Cambridge, England) · 2016Article
- Caenorhabditis elegans polo-like kinase PLK-1 is required for merging parental genomes into a single nucleus.Molecular biology of the cell · 2015Article
- Cell-cycle quiescence maintains Caenorhabditis elegans germline stem cells independent of GLP-1/Notch.eLife · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several mitotic regulators, including Cyclin B1/Cdk1, are present at centrosomes prior to mitosis onset, but it is unclear whether centrosomes promote mitotic entry in vivo. Here we developed a sensitive assay in C. elegans embryos for the temporal analysis of mitotic entry, in which the male and female pronuclei undergo asynchronous entry into mitosis when separated from one another. Using this assay, we found that centrosome integrity is necessary for timing mitotic entry. Centrosomes do not function in this instance through their ability to nucleate microtubules. Instead, centrosomes serve to focus the Aurora A kinase AIR-1, which is essential for timely mitotic entry. Furthermore, analysis of embryos in which centrosomes and pronuclei are detached from one another demonstrates that centrosomes are sufficient to promote mitosis onset. Together, our findings support a model in which centrosomes serve as integrative centers for mitotic regulators and thus trigger mitotic entry in a timely fashion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.