ArticleBMC medical genetics2007
Genetic mapping of a new heart rate QTL on chromosome 8 of spontaneously hypertensive rats.
Article in BMC medical genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Hunting for Genes Underlying Emotionality in the Laboratory Rat: Maps, Tools and Traps.Current neuropharmacology · 2023Review
- Article
- Towards Precision Medicine for Hypertension: A Review of Genomic, Epigenomic, and Microbiomic Effects on Blood Pressure in Experimental Rat Models and Humans.Physiological reviews · 2017Review
- Article
- The influence of sex and estrous cycle on QTL for emotionality and ethanol consumption.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- Genome Scan for Parent-of-Origin QTL Effects on Bovine Growth and Carcass Traits.Frontiers in genetics · 2011Article
- Expression of alpha-synuclein is increased in the hippocampus of rats with high levels of innate anxiety.Molecular psychiatry · 2009Article
- Blood pressure and heart rate QTL in mice of the B6/D2 lineage: sex differences and environmental influences.Physiological genomics · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTachycardia is commonly observed in hypertensive patients, predominantly mediated by regulatory mechanisms integrated within the autonomic nervous system. The genetic loci and genes associated with increased heart rate in hypertension, however, have not yet been identified.
methodsAn F2 intercross of Spontaneously Hypertensive Rats (SHR) x Brown Norway (BN) linkage analysis of quantitative trait loci mapping was utilized to identify candidate genes associated with an increased heart rate in arterial hypertension.
resultsBasal heart rate in SHR was higher compared to that of normotensive BN rats (365 +/- 3 vs. 314 +/- 6 bpm, p < 0.05 for SHR and BN, respectively). A total genome scan identified one quantitative trait locus in a 6.78 cM interval on rat chromosome 8 (8q22-q24) that was responsible for elevated heart rate. This interval contained 241 genes, of which 65 are known genes.
conclusionOur data suggest that an influential genetic region located on the rat chromosome 8 contributes to the regulation of heart rate. Candidate genes that have previously been associated with tachycardia and/or hypertension were found within this QTL, strengthening our hypothesis that these genes are, potentially, associated with the increase in heart rate in a hypertension rat model.
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