Evidence map›Paper›PMID 17418821›Full record

ArticleFEBS letters2007

Up-regulation of the Ku heterodimer in Drosophila testicular cyst cells.

Alexander M Boutanaev, Lyudmila M Mikhaylova, Dmitry I Nurminsky

Open access · greenAbstract read
In one paragraph

Article in FEBS letters, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Alexander M BoutanaevTufts University School of Medicine, Department of Anatomy and Cellular Biology, 136 Harrison Avenue, Boston, MA 02111, United States.
Lyudmila M Mikhaylova
Dmitry I Nurminsky
Tufts University · US

Funding

TRANSCRIPTIONAL REGULATION IN DROSOPHILA SPERMATOGENESISR01GM061549 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI NURMINSKY, DMITRY I · 2000 to 2010
$1.7M
NIGMS NIH HHS GM61549NIGMS NIH HHS R01 GM061549
6 · The paper itself

Abstract

In Drosophila, developing germline cysts in testis are enveloped by two somatic cyst cells essential for germline development and male reproduction. The cyst cells continue development along with the germline. However, the mechanisms of somatic gene expression in testes are poorly understood. We report transcriptional up-regulation of the Ku heterodimer in cyst cells. The initial up-regulation is independent of germline, and transcription is further augmented during spermatogenesis. Abundance of Ku in the cyst cell cytoplasm suggests the role for Ku subunits in the regulation of sperm individualization.

Indexed as

Up-RegulationAnimalsAntigens, NuclearDimerizationDNA-Binding ProteinsDrosophilaKu AutoantigenMaleMeiosisProtein SubunitsTestisTranscription, GeneticAntigens, NuclearDNA-Binding ProteinsKu AutoantigenProtein Subunits

Identifiers

PMID17418821
PMCPMC1992518
OpenAlexW2059605364

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.