ArticleActa biomaterialia2007
Synthesis and characterization of segmented poly(esterurethane urea) elastomers for bone tissue engineering.
Article in Acta biomaterialia, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 102 citations in OpenAlex.
- Article
- Development of Small-Diameter Silk Vascular Grafts Supported by Solid-State Nuclear Magnetic Resonance Structural Analysis.Molecules (Basel, Switzerland) · 2025Review
- Bioactive Composite for Orbital Floor Repair and Regeneration.International journal of molecular sciences · 2022Article
- Characterization of a Water-Dispersed Biodegradable Polyurethane-Silk Composite Sponge UsingMolecules (Basel, Switzerland) · 2021Article
- Review
- Article
- Synthesis and in Vitro Cytocompatibility of Segmented Poly(Ester-Urethane)s and Poly(Ester-Urea-Urethane)s for Bone Tissue Engineering.Polymers · 2018Article
- Synthesis and Characterization of Polycaprolactone-Based Polyurethanes for the Fabrication of Elastic Guided Bone Regeneration Membrane.BioMed research international · 2018Article
- Biocompatible, degradable thermoplastic polyurethane based on polycaprolactone-block-polytetrahydrofuran-block-polycaprolactone copolymers for soft tissue engineering.Journal of materials chemistry. B · 2017Article
- Rapidly Biodegrading PLGA-Polyurethane Fibers for Sustained Release of Physicochemically Diverse Drugs.ACS biomaterials science & engineering · 2016Article
- Cell layer-electrospun mesh composites for coronary artery bypass grafts.Journal of biomedical materials research. Part A · 2016Article
- Elastomeric enriched biodegradable polyurethane sponges for critical bone defects: a successful case study reducing donor site morbidity.Journal of materials science. Materials in medicine · 2016Article
- Human mesenchymal stem cell behavior on segmented polyurethanes prepared with biologically active chain extenders.Journal of materials science. Materials in medicine · 2016Article
- Synthesis and characterization of novel elastomeric poly(D,L-lactide urethane) maleate composites for bone tissue engineering.European polymer journal · 2013Article
- Degradable segmented polyurethane elastomers for bone tissue engineering: effect of polycaprolactone content.Journal of biomaterials science. Polymer edition · 2013Article
- Progress and challenges in biomaterials used for bone tissue engineering: bioactive glasses and elastomeric composites.Progress in biomaterials · 2012Article
- Injectable polyurethane composite scaffolds delay wound contraction and support cellular infiltration and remodeling in rat excisional wounds.Journal of biomedical materials research. Part A · 2012Article
- Effect of pulse frequency on the osteogenic differentiation of mesenchymal stem cells in a pulsatile perfusion bioreactor.Journal of biomechanical engineering · 2011Article
- The dependence of MG63 osteoblast responses to (meth)acrylate-based networks on chemical structure and stiffness.Biomaterials · 2010Article
- Ability of polyurethane foams to support placenta-derived cell adhesion and osteogenic differentiation: preliminary results.Journal of materials science. Materials in medicine · 2010Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Segmented polyurethanes have been used extensively in implantable medical devices, but their tunable mechanical properties make them attractive for examining the effect of biomaterial modulus on engineered musculoskeletal tissue development. In this study, a family of segmented degradable poly(esterurethane urea)s (PEUURs) were synthesized from 1,4-diisocyanatobutane, a poly(epsilon-caprolactone) (PCL) macrodiol soft segment and a tyramine-1,4-diisocyanatobutane-tyramine chain extender. By systematically increasing the PCL macrodiol molecular weight from 1100 to 2700Da, the storage modulus, crystallinity and melting point of the PCL segment were systematically varied. In particular, the melting temperature, T(m), increased from 21 to 61 degrees C and the storage modulus at 37 degrees C increased from 52 to 278MPa with increasing PCL macrodiol molecular weight, suggesting that the crystallinity of the PCL macrodiol contributed significantly to the mechanical properties of the polymers. Bone marrow stromal cells were cultured on rigid polymer films under osteogenic conditions for up to 21 days. Cell density, alkaline phosphatase activity, and osteopontin and osteocalcin expression were similar among PEUURs and comparable to poly(d,l-lactic-coglycolic acid). This study demonstrates the suitability of this family of PEUURs for tissue engineering applications, and establishes a foundation for determining the effect of biomaterial modulus on bone tissue development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.