ArticleProceedings of the National Academy of Sciences of the United States of America2007
Tale of two spikes in bacteriophage PRD1.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Structure of NO16, a marine non-tailed vibriophage with an unusual symmetry-mismatched vertex arrangement.PLoS pathogens · 2026Article
- Architecture and Assembly of Structurally Complex Viruses.Sub-cellular biochemistry · 2024Review
- Viruses of theFrontiers in microbiology · 2023Review
- Cryo-EM structure of ssDNA bacteriophage ΦCjT23 provides insight into early virus evolution.Nature communications · 2022Article
- Environmental Effects on Viable Virus Transport and Resuspension in Ventilation Airflow.Viruses · 2022Article
- A packing for A-form DNA in an icosahedral virus.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- Image processing for cryogenic transmission electron microscopy of symmetry-mismatched complexes.Bioscience reports · 2018Article
- Membrane-containing virus particles exhibit the mechanics of a composite material for genome protection.Nanoscale · 2018Article
- Review
- Components of Adenovirus Genome Packaging.Frontiers in microbiology · 2016Review
- Localized reconstruction of subunits from electron cryomicroscopy images of macromolecular complexes.Nature communications · 2015Article
- A structural model of the genome packaging process in a membrane-containing double stranded DNA virus.PLoS biology · 2014Article
- Two novel proteins of cyanophage Syn5 compose its unusual horn structure.Journal of virology · 2014Article
- Identification of a ligand on the Wip1 bacteriophage highly specific for a receptor on Bacillus anthracis.Journal of bacteriology · 2013Article
- Article
- Structure and assembly of complex viruses.Sub-cellular biochemistry · 2013Review
- Interaction of alphaVbeta3 and alphaVbeta6 integrins with human parechovirus 1.Journal of virology · 2010Article
- Familial relationships in hyperthermo- and acidophilic archaeal viruses.Journal of virology · 2010Article
- Structure and host-cell interaction of SH1, a membrane-containing, halophilic euryarchaeal virus.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Structural comparisons between bacteriophage PRD1 and adenovirus have revealed an evolutionary relationship that has contributed significantly to current ideas on virus phylogeny. However, the structural organization of the receptor-binding spike complex and how the different symmetry mismatches are mediated between the spike-complex proteins are not clear. We determined the architecture of the PRD1 spike complex by using electron microscopy and three-dimensional image reconstruction of a series of PRD1 mutants. We constructed an atomic model for the full-length P5 spike protein by using comparative modeling. P5 was shown to be bound directly to the penton base protein P31. P5 and the receptor-binding protein P2 form two separate spikes, interacting with each other near the capsid shell. P5, with a tumor necrosis factor-like head domain, may have been responsible for host recognition before capture of the current receptor-binding protein P2.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.