ArticleJournal of bacteriology2007
Purification and characterization of mycobacterial phospholipase A: an activity associated with mycobacterial cutinase.
Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 52 citations in OpenAlex.
- Article
- High-Throughput, Fluorescence-Based Esterase Activity Assay for Assessing Polysorbate Degradation Risk during Biopharmaceutical Development.Pharmaceutical research · 2021Article
- Seasonal dynamics and starvation impact on the gut microbiome of urochordate ascidian Halocynthia roretzi.Animal microbiome · 2020Article
- Exploring the Enzymatic and Antibacterial Activities of Novel Mycobacteriophage Lysin B Enzymes.International journal of molecular sciences · 2020Article
- Rv3091, An Extracellular Patatin-Like Phospholipase inFrontiers in microbiology · 2020Article
- Biochemical Characterization of Isoniazid-resistantMolecular & cellular proteomics : MCP · 2018Article
- In vivo evolution of drug-resistant Mycobacterium tuberculosis in patients during long-term treatment.BMC genomics · 2018Article
- Bacterial Sphingomyelinases and Phospholipases as Virulence Factors.Microbiology and molecular biology reviews : MMBR · 2016Review
- An Invertron-Like Linear Plasmid Mediates Intracellular Survival and Virulence in Bovine Isolates of Rhodococcus equi.Infection and immunity · 2015Article
- Article
- Interaction of alveolar epithelial cells with CFP21, a mycobacterial cutinase-like enzyme.Molecular and cellular biochemistry · 2014Article
- Expression of antimicrobial drug tolerance by attached communities of Mycobacterium tuberculosis.Pathogens and disease · 2014Article
- Extracellular location of Thermobifida fusca cutinase expressed in Escherichia coli BL21(DE3) without mediation of a signal peptide.Applied and environmental microbiology · 2013Article
- A low molecular mass cutinase of Thielavia terrestris efficiently hydrolyzes poly(esters).Journal of industrial microbiology & biotechnology · 2013Article
- Article
- Synthesis and kinetic evaluation of cyclophostin and cyclipostins phosphonate analogs as selective and potent inhibitors of microbial lipases.Journal of medicinal chemistry · 2012Article
- Article
- Comparative and functional genomics of Rhodococcus opacus PD630 for biofuels development.PLoS genetics · 2011Article
- Mycobacterium tuberculosis lipolytic enzymes as potential biomarkers for the diagnosis of active tuberculosis.PloS one · 2011Article
- The genome of a pathogenic rhodococcus: cooptive virulence underpinned by key gene acquisitions.PLoS genetics · 2010Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We describe mycobacterial phospholipase A activity (MPLA) and, using reverse genetics, have associated this activity with putative mycobacterial cutinase. PLAs, which hydrolyze fatty acids on phospholipids, play a significant role in human inflammatory states and disease pathogenesis. In prokaryotes, the recognition of their role in virulence is more recent. Cutinases are serine esterases whose primary substrate is cutin, the waxy exterior layer of plants. Mycobacterium tuberculosis has maintained seven putative cutinases, though it should not encounter cutin; we demonstrate that known cutinases and MPLA cleave phospholipids in a PLA-type manner and also hydrolyze Tween. We analyzed cutinase motifs in mycobacteria and found the motif very prevalent. All mycobacteria tested had MPLA activity. These studies suggest an alternative use for putative cutinases by the M. tuberculosis group that is likely related to MPLA activity and lipid metabolism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.