ArticleJournal of bacteriology2007
Structural properties of periplasmic SodCI that correlate with virulence in Salmonella enterica serovar Typhimurium.
Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Salmonellosis: An Overview of Epidemiology, Pathogenesis, and Innovative Approaches to Mitigate the Antimicrobial Resistant Infections.Antibiotics (Basel, Switzerland) · 2024Review
- Genome characterization ofFrontiers in microbiology · 2024Article
- Pan msr gene deleted strain of Salmonella Typhimurium suffers oxidative stress, depicts macromolecular damage and attenuated virulence.Scientific reports · 2023Article
- Old dogs, new tricks: New insights into the iron/manganese superoxide dismutase family.Journal of inorganic biochemistry · 2022Article
- Genomic analysis reveals high intra-species diversity ofMicrobial genomics · 2022Article
- Action of carvacrol in Salmonella Typhimurium biofilm: A proteomic study.Journal of applied biomedicine · 2020Article
- Four superoxide dismutases of Bacillus cereus 0-9 are non-redundant and perform different functions in diverse living conditions.World journal of microbiology & biotechnology · 2020Article
- Perforin-2 Breaches the Envelope of Phagocytosed Bacteria Allowing Antimicrobial Effectors Access to Intracellular Targets.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Chemical Warfare at the Microorganismal Level: A Closer Look at the Superoxide Dismutase Enzymes of Pathogens.ACS infectious diseases · 2018Review
- Cytoplasmic Copper Detoxification in Salmonella Can Contribute to SodC Metalation but Is Dispensable during Systemic Infection.Journal of bacteriology · 2017Article
- Periplasmic superoxide dismutase SodCI of Salmonella binds peptidoglycan to remain tethered within the periplasm.Molecular microbiology · 2015Article
- Heterologous expression and biochemical characterization of a highly active and stable chloroplastic CuZn-superoxide dismutase from Pisum sativum.BMC biotechnology · 2015Article
- A primary role for disulfide formation in the productive folding of prokaryotic Cu,Zn-superoxide dismutase.The Journal of biological chemistry · 2014Article
- Mechanisms of copper homeostasis in bacteria.Frontiers in cellular and infection microbiology · 2013Article
- Either periplasmic tethering or protease resistance is sufficient to allow a SodC to protect Salmonella enterica serovar Typhimurium from phagocytic superoxide.Molecular microbiology · 2011Article
- The roles of metal ions in regulation by riboswitches.Metal ions in life sciences · 2011Review
- Protecting against antimicrobial effectors in the phagosome allows SodCII to contribute to virulence in Salmonella enterica serovar Typhimurium.Journal of bacteriology · 2010Article
- Salmonella--the ultimate insider. Salmonella virulence factors that modulate intracellular survival.Cellular microbiology · 2009Review
- Proteome of Salmonella Enterica Serotype Typhimurium Grown in a Low Mg/pH Medium.Journal of proteomics & bioinformatics · 2009Article
- Phagocytic superoxide specifically damages an extracytoplasmic target to inhibit or kill Salmonella.PloS one · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Salmonella enterica strains survive and propagate in macrophages by both circumventing and resisting the antibacterial effectors normally delivered to the phagosome. An important aspect of Salmonella resistance is the production of periplasmic superoxide dismutase to combat phagocytic superoxide. S. enterica serovar Typhimurium strain 14028 produces two periplasmic superoxide dismutases: SodCI and SodCII. Both enzymes are produced during infection, but only SodCI contributes to virulence in the animal. Although 60% identical to SodCII at the amino acid level with very similar enzymatic properties, SodCI is dimeric, protease resistant, and tethered within the periplasm via a noncovalent interaction. In contrast, SodCII is monomeric and protease sensitive and is released from the periplasm normally by osmotic shock. We have constructed an enzymatically active monomeric SodCI enzyme by site-directed mutagenesis. The resulting protein was released by osmotic shock and sensitive to protease and could not complement the loss of wild-type dimeric SodCI during infection. To distinguish which property is most critical during infection, we cloned and characterized related SodC proteins from a variety of bacteria. Brucella abortus SodC was monomeric and released by osmotic shock but was protease resistant and could complement SodCI in the animal. These data suggest that protease resistance is a critical property that allows SodCI to function in the harsh environment of the phagosome to combat phagocytic superoxide. We propose a model to account for the various properties of SodCI and how they contribute to bacterial survival in the phagosome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.