ArticleBiophysical journal2007
Membrane-binding/modification model of signaling protein activation and analysis of its control by cell morphology.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 11 citations in OpenAlex.
- Sortase A-Mediated Farnesylation of Cdc42ACS synthetic biology · 2026Article
- Morphological control of merlin-Rac antagonism in proliferation-promoting signaling.Science signaling · 2025Article
- Mechanotransduction as a major driver of cell behaviour: mechanisms, and relevance to cell organization and future research.Open biology · 2021Review
- Mechanistic models of PLC/PKC signaling implicate phosphatidic acid as a key amplifier of chemotactic gradient sensing.PLoS computational biology · 2020Article
- A Reaction-Diffusion Model Explains Amplification of the PLC/PKC Pathway in Fibroblast Chemotaxis.Biophysical journal · 2017Article
- Formation of morphogen gradients: local accumulation time.Physical review. E, Statistical, nonlinear, and soft matter physics · 2011Article
- Directional persistence of cell migration coincides with stability of asymmetric intracellular signaling.Biophysical journal · 2010Article
- Use of virtual cell in studies of cellular dynamics.International review of cell and molecular biology · 2010Review
- Analysis of reaction-diffusion systems with anomalous subdiffusion.Biophysical journal · 2009Article
- Model for Protein Concentration Gradients in the Cytoplasm.Cellular and molecular bioengineering · 2008Article
- How Cells feel their environment: a focus on early dynamic events.Cellular and molecular bioengineering · 2008Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
A mechanism for cell shape control of intracellular signal transduction, whereby the average concentration of activated proteins in the cytosol increases as the height of the cell decreases, has been described recently. An important modification of this analysis is offered, recognizing that signaling proteins are not only activated at the plasma membrane but must first form complexes with signaling molecules that reside there, such as receptors and lipids. With these more realistic boundary conditions, it is shown that the region of parameter space where cell shape amplifies the average cytosolic activity is greatly expanded. Moreover, this model allows for amplification of the activated protein bound at the membrane, which is considered more relevant for certain, spatially driven signaling processes in cell migration.
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Registered trials
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