ArticleThe Journal of biological chemistry2007
FoxP3 enhances HIV-1 gene expression by modulating NFkappaB occupancy at the long terminal repeat in human T cells.
Article in The Journal of biological chemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 46 citations in OpenAlex.
- Replication-competent SIVcpz CRISPR screen identifies barriers to successful cross-species transmission.Journal of virology · 2026Article
- Characterizing the Latent HIV-1 Reservoir in Patients with Viremia Suppressed on cART: Progress, Challenges, and Opportunities.Current HIV research · 2020Article
- Schistosoma mansoni soluble egg antigen (SEA) and recombinant Omega-1 modulate induced CD4+ T-lymphocyte responses and HIV-1 infection in vitro.PLoS pathogens · 2019Article
- CD4AIDS research and human retroviruses · 2018Review
- Regulatory T Cells Contribute to HIV-1 Reservoir Persistence in CD4+ T Cells Through Cyclic Adenosine Monophosphate-Dependent Mechanisms in Humanized Mice In Vivo.The Journal of infectious diseases · 2017Article
- Diversity of HIV-1 reservoirs in CD4+ T-cell subpopulations.Current opinion in HIV and AIDS · 2016Review
- Expansion and productive HIV-1 infection of Foxp3 positive CD4 T cells at pleural sites of HIV/TB co-infection.Journal of clinical & experimental immunology · 2016Article
- Th1/17 Polarization of CD4 T Cells Supports HIV-1 Persistence during Antiretroviral Therapy.Journal of virology · 2015Article
- Pim-2 Kinase Influences Regulatory T Cell Function and Stability by Mediating Foxp3 Protein N-terminal Phosphorylation.The Journal of biological chemistry · 2015Article
- Sex-based differences in HIV type 1 pathogenesis.The Journal of infectious diseases · 2014Review
- Epigenetic modification of FOXP3 in patients with chronic HIV infection.Journal of acquired immune deficiency syndromes (1999) · 2014Article
- Immune quiescence: a model of protection against HIV infection.Retrovirology · 2013Review
- T Cell Transcription Factors and Their Impact on HIV Expression.Virology : research and treatment · 2013Article
- Molecular and biological role of the FOXP3 N-terminal domain in immune regulation by T regulatory/suppressor cells.Experimental and molecular pathology · 2012Review
- Homeostasis and function of regulatory T cells in HIV/SIV infection.Journal of virology · 2012Review
- Forkhead transcription factor FOXP3 upregulates CD25 expression through cooperation with RelA/NF-κB.PloS one · 2012Article
- Article
- Altered phenotype of regulatory T cells associated with lack of human immunodeficiency virus (HIV)-1-specific suppressive function.Clinical and experimental immunology · 2011Article
- FoxP3 interacts with linker histone H1.5 to modulate gene expression and program Treg cell activity.Genes and immunity · 2011Article
- Regulation of IL-2 gene expression by Siva and FOXP3 in human T cells.BMC immunology · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
FoxP3 determines the development of CD4+CD25+ regulatory T (Treg) cells and represses interleukin-2 (IL-2) expression in Treg cells. However, human immunodeficiency virus type 1 (HIV-1) infects and replicates efficiently in FoxP3+ Treg cells. We report that, while inhibiting IL-2 gene expression, FoxP3 enhances gene expression from HIV-1 long terminal repeat (LTR). This FoxP3 activity requires both the N- and C-terminal domains and is inactivated by human IPEX (immunodysregulation, polyendocrinopathy, enteropathy, X-linked syndrome) mutations. FoxP3 enhances HIV-1 LTR via its specific NFkappaB binding sequences in an NFkappaB-dependent fashion in T cells but not in HEK293 cells. FoxP3 decreases level of histone acetylation at the interleukin-2 locus but not at the HIV-1 LTR. Although NFkappaB nuclear translocation is not altered, FoxP3 enhances NFkappaB-p65 binding to HIV-1 LTR. These data suggest that FoxP3 modulates gene expression in a promoter sequence-dependent fashion by modulating chromatin structure and NFkappaB activity. HIV-1 LTR has evolved to both highjack the T-cell activation pathway for expression and to resist FoxP3-mediated suppression of T-cell activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.