ArticleTransgenic research2008
Accumulation of vitamin E in potato (Solanum tuberosum) tubers.
Article in Transgenic research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 66 citations in OpenAlex.
- An alternative splicing caused by a natural variation in BnaC02.VTE4 gene affects vitamin E and glucosinolate content in rapeseed (Brassica napus L.).Plant biotechnology journal · 2025Article
- Review
- Recent Advances in Molecular Improvement for Potato Tuber Traits.International journal of molecular sciences · 2022Review
- Antioxidants in Potatoes: A Functional View on One of the Major Food Crops Worldwide.Molecules (Basel, Switzerland) · 2021Review
- Article
- Employing CRISPR/Cas Technology for the Improvement of Potato and Other Tuber Crops.Frontiers in plant science · 2021Review
- Rapid enhancement of α-tocopherol content in3 Biotech · 2018Article
- Tocopherol levels in different mango varieties correlate with3 Biotech · 2017Article
- P-HYDROXYPHENYLPYRUVATE DIOXYGENASE from Medicago sativa is involved in vitamin E biosynthesis and abscisic acid-mediated seed germination.Scientific reports · 2017Article
- Potential of golden potatoes to improve vitamin A and vitamin E status in developing countries.PloS one · 2017Article
- Manipulation of Metabolic Pathways to Develop Vitamin-Enriched Crops for Human Health.Frontiers in plant science · 2017Review
- Selection and molecular characterization of a high tocopherol accumulation rice mutant line induced by gamma irradiation.Molecular biology reports · 2014Article
- Translational research in agricultural biology-enhancing crop resistivity against environmental stress alongside nutritional quality.Frontiers in chemistry · 2014Article
- Increased α-tocotrienol content in seeds of transgenic rice overexpressing Arabidopsis γ-tocopherol methyltransferase.Transgenic research · 2013Article
- Gene transfer into Solanum tuberosum via Rhizobium spp.Transgenic research · 2011Article
- Article
- Characterization and expression profiling of 4-hydroxyphenylpyruvate dioxygenase gene (Smhppd) from Salvia miltiorrhiza hairy root cultures.Molecular biology reports · 2009Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin E (tocopherol) is a powerful antioxidant essential for human health and synthesized only by photosynthetic organisms. The effects of over-expression of tocopherol biosynthetic enzymes have been studied in leaves and seeds, but not in a non-photosynthetic, below-ground plant organ. Genetic and molecular approaches were used to determine if increased levels of tocopherols can be accumulated in potato (Solanum tuberosum L.) tubers through metabolic engineering. Two transgenes were constitutively over-expressed in potato: Arabidopsis thaliana p-hydroxyphenylpyruvate dioxygenase (At-HPPD) and A. thaliana homogentisate phytyltransferase (At-HPT). alpha-Tocopherol levels in the transgenic plants were determined by high-performance liquid chromatography. In potato tubers, over-expression of At-HPPD resulted in a maximum 266% increase in alpha-tocopherol, and over-expression of At-HPT yielded a 106% increase. However, tubers from transgenic plants still accumulated approximately 10- and 100-fold less alpha-tocopherol than leaves or seeds, respectively. The results indicate that physiological and regulatory constraints may be the most limiting factors for tocopherol accumulation in potato tubers. Studying regulation and induction of tocopherol biosynthesis should reveal approaches to more effectively engineer crops with enhanced tocopherol content.
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Registered trials
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