ArticleJournal of clinical neurophysiology : official publication of the American Electroencephalographic Society2007
Tonic-clonic transitions in computer simulation.
Article in Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Ephaptic conduction in tonic-clonic seizures.Frontiers in neurology · 2024Article
- Training spiking neuronal networks to perform motor control using reinforcement and evolutionary learning.Frontiers in computational neuroscience · 2022Article
- Modeling Neurotransmission: Computational Tools to Investigate Neurological Disorders.International journal of molecular sciences · 2021Review
- Multiscale recordings reveal the dynamic spatial structure of human seizures.Neurobiology of disease · 2019Review
- Multitarget Multiscale Simulation for Pharmacological Treatment of Dystonia in Motor Cortex.Frontiers in pharmacology · 2016Article
- Cortical Spiking Network Interfaced with Virtual Musculoskeletal Arm and Robotic Arm.Frontiers in neurorobotics · 2015Article
- Motor cortex microcircuit simulation based on brain activity mapping.Neural computation · 2014Article
- Towards a real-time interface between a biomimetic model of sensorimotor cortex and a robotic arm.Pattern recognition letters · 2014Article
- Reinforcement learning of two-joint virtual arm reaching in a computer model of sensorimotor cortex.Neural computation · 2013Article
- The virtual brain integrates computational modeling and multimodal neuroimaging.Brain connectivity · 2013Article
- Cortical information flow in Parkinson's disease: a composite network/field model.Frontiers in computational neuroscience · 2013Article
- Reinforcement learning of targeted movement in a spiking neuronal model of motor cortex.PloS one · 2012Article
- Synaptic information transfer in computer models of neocortical columns.Journal of computational neuroscience · 2011Article
- Emergence of physiological oscillation frequencies in a computer model of neocortex.Frontiers in computational neuroscience · 2011Article
- Just-in-time connectivity for large spiking networks.Neural computation · 2008Article
- Computer modelling of epilepsy.Nature reviews. Neuroscience · 2008Review
- The virtual slice setup.Journal of neuroscience methods · 2008Article
- Computational models of epileptic activity: a bridge between observation and pathophysiological interpretation.Expert review of neurotherapeutics · 2008Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
summaryNetwork simulations can help identify underlying mechanisms of epileptic activity that are hard to isolate in biologic preparations. To be useful, simulations must be sufficiently realistic to make possible biologic and clinical prediction. This requirement for large networks of sufficiently detailed neurons raises challenges both with regard to computational load and the difficulty of obtaining insights with large numbers of free parameters and the large amounts of generated data. The authors have addressed these problems by simulating computationally manageable networks of moderate size consisting of 1,000 to 3,000 neurons with multiple intrinsic and synaptic properties. Experiments on these simulations demonstrated the presence of epileptiform behavior in the form of repetitive high-intensity population events (clonic behavior) or latch-up with near maximal activity (tonic behavior). Intrinsic neuronal excitability is not always a predictor of network epileptiform activity but may paradoxically produce antiepileptic effects, depending on the settings of other parameters. Several simulations revealed the importance of random coincident inputs to shift a network from a low-activation to a high-activation epileptiform state. Finally, a simulated anticonvulsant acting on excitability tended to preferentially decrease tonic activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.